Methods of Assessing the Reinforcing Properties of Abused Drugs

Self-Administration Studies.- 1: Intravenous self-administration: Response rates, the effects of pharmacological challenges, and drug preferences.- 2: Screening for drug reinforcement using intravenous self-administration in the rat.- 3: Assessing drugs for abuse liability and dependence potential in laboratory primates.- 4: Interpretation of lesion effects on stimulant self-administration.- 5: Second-order schedules of drug injection.- 6: Intravenous drug self-administrations A special case of positive reinforcement.- 7: Oral drug self-administrations Drugs as reinforcers.- 8: Oral self-administration of alcohols A valid approach to the study of drug self-administration and human alcoholism.- 9: Intracranial self-administration procedures for the assessment of drug reinforcement.- 10: Prediction of drug abuse liability from animal studies.- Conditioning Studies.- 11: Conditioned reinforcement as a measure of the rewarding properties of drugs.- 12: Reinstatement of drug-taking behavior as a method of assessing incentive motivational properties of drugs.- 13: Place conditionings A simple and effective method for assessing the motivational properties of drugs.- 14: Conditioned place preferences A parametric analysis using systemic heroin injections.- 15: Anatomical and neurochemical substrates of drug reward determined by the conditioned place preference technique.- Drug Discrimination Studies.- 16: Applications and limitations of the drug discrimination method for the study of drug abuse.- 17: Drug discriminations Methods of manipulation, measurement, and analysis.- 18: The study of structure-activity relationships using drug discrimination methodology.- Brain Stimulation Reward Studies.- 19: Tests involving pressing for intracranial stimulation as an early procedure forscreening likelihood of addiction of opioids and other drugs.- 20: Brain-stimulation rewards Measurement and mapping by psychophysical techniques and quantitative 2-[14C] deoxyglucose