Microbial Cyclic Di-Nucleotide Signaling

Part I:Biochemistry/Structural Biology - Enzymes.- Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria.- Chapter 2: Structure and regulation of EAL domain proteins.- Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins.- Chapter 4: Structure and function of HD-GYP phosphodiesterases.- Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases.- Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides.- Part II:Biochemistry/Structural Biology - Receptors.- Chapter 7: Detection of cyclic dinucleotide binding proteins.- Chapter 8: Non-canonical c-di-GMP binding modes.- Part III:Biochemistry/Structural Biology - Sensing.- Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction.- Part IV:Cyclic di-AMP biochemistry and physiology.- Chapter 10: Metabolic regulationby cyclic di-AMP signaling.- Chapter 11: Osmoregulation via cyclic-di-AMP signaling.- Part V:Population diversity.- Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity.-Part VI:Cyclic di-GMP and exopolysaccharide regulation.- Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP.- Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling.- Part VII:Environmental bacteria.- Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis.- Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group.- Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation.-Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus.- Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria.- Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter.- Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria.- Part VIII:Pathogens.-

Shan-Ho Chou is currently a chair professor of the Institute of Biochemistry, National Chung Hsing University, Taiwan. He received his bachelor's degree in chemistry from the National Taiwan Normal University, a master's degree in biochemistry from the National Taiwan University, and a Ph.D. in chemistry from the University of Washington in Seattle, WA. He has been interested in studying protein and unusual nucleic acid complex structures and found several stable nucleic acid structures different from the WC base-paired duplex, which were published in several review papers in the Journal of Molecular Biology, Nucleic Acids Research and Trends in Biochemistry. He is now combining X-ray, nuclear magnetic resonance, and cryo-electron microscopy techniques to study the structures and functions of multi-domain proteins complexed with cyclic di-GMP and cyclic di-AMP.

Nicolas Giuliani received his PhD from the UniversitéAix-Marseille, France. He is actually full professor of Microbiology and Biotechnology at the Facultad de Ciencias, Universidad de Chile in Santiago, Chile.  His research is focused on the deciphering of molecular events involved in biofilm formation by acidophilic bacteria currently used in biomining processes. Initially focused on the characterization of quorum sensing systems, his research activities are now dealing with cyclic di-nucleotide second messenger signalling and the regulation of exopolysaccharides in Acidithiobacillus species. Nicolas Guiliani was President of the Chilean Society of Microbiology (SOMICH, 2013-2016) and President of the Association of Latinamerican Societies for Microbiology (ALAM, 2016-2018).

Vincent T. Lee is professor of Cell Biology and Molecular Genetics at the University of Maryland at College Park, USA. His long-standing research interests include bacterial pathogenesis, biofilm formation and regulation