Microbial DNA and Host Immunity
(Sprache: Englisch)
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the...
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Klappentext zu „Microbial DNA and Host Immunity “
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Inhaltsverzeichnis zu „Microbial DNA and Host Immunity “
Part I. IntroductionImmunostimulatory DNA: An Overview
Eyal Raz
Historical Perspectives
Saburo Yamamoto, Toshiko Yamamoto, and Tohru Tokunaga
Part II. Receptors and Signaling
Signal Transduction Pathways Activated by CpG-DNA
Hans Häcker
A Novel Toll-Like Receptor that Recognizes Bacterial DNA
Hiroaki Hemmi and Shizuo Akira
Activation of Innate Immunity by Microbial Nucleic Acids
Wen-Ming Chu, Xing Gong, and Tony Yoon
Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG
Katryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, and David A. Hume
Part III. Cell Activation
Activation of NK Cell by Immunostimulatory Oligo-DNA in Mouse and Human
Saburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, and Tohru Tokunaga
Regulation of Antigen Presenting Cell Function by CpG-DNA
David Askew, Rose S. Chu, and Clifford V. Harding
Activation of B Cells by CpG Motifs in Bacterial DNA, Ae-Kyung Yi and Arthur M. Krieg
IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells
Jonathan Sprent
Cross Priming of CD8+ T Cells by Immunostimulatory Sequence DNA
Hearn Jay Cho, Sandip Datta, and Eyal Raz
Part IV. Vaccination Strategies
The Th1 Adjuvant Effect of Immunostimulatory DNA Sequences
Maripat Corr and Chih Min Tang
Immunostimulatory DNA Pre-Priming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses
Hiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, and Anthony A. Horner
Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen
Kenji Takabayashi, Helen Tighe, Lucinda Beck, and Hans L. Spiegelberg
Immunostimulatory DNA Sequence-Based Mucosal Vaccines
Anthony A. Horner
Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence by Liposomal Delivery
Eli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi, and Yechezkel
... mehr
Barenholz.
Immunostimulatory Sequences in Plasmid Vectors
Christina C. N. Wu, Chih Min Tang, Brian Crain, and Maripat Corr
Part V. Applications-Infectious Disease
Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B
Michael J. McCluskie, Risini D. Weeratna, and Heather L. Davis
Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine?
Sandip K. Datta, Anthony A. Horner, Kenji Takabayashi, and Eyal Raz
Immunoprotective Activity of CpG Oligonucleotides
Dennis M. Klinman, Ken J. Ishii, and Ihsan Gursel
Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection
Tomoko Hayashi, Christine H. Tran, Lucinda Beck, Savita Rao, and Antonino Cantanzaro
Part VI. Applications-Allergy
DNA-Based Immunotherapeutics for Allergic Disease
Anthony A. Horner and Eyal Raz
Immunostimulatory DNA for Allergic Asthma
Reid K. Ikeda, Kenji Takabayashi, and David Broide
CpG Oligodeoxynucleotides in Asthma
Kunihiko Kitagaki and Joel N. Kline
Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides
Andrea Keane-Myers and Chi-Chao Chan
Part VII. Applications-Cancer
CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma
Thomas L. Warren and George J. Weiner
Part VIII. Inflammation and Autoimmunity
The Antigenicity of Bacterial DNA
David S. Pisetsky
Inflammatogenic Properties of Immunostimulatory DNA Sequences
Andrej Tarkowski, L. Vincent Collins, Guo-Min Deng, and Leno Mölne
The Role of Immunostimulatory DNA Sequences in Arthritis
Sarah T.A. Roord, Arash Ronaghy, Berent J. Prakken, Kenji Takabayashi, and Dennis A. Carson
Effects of Immunostimulatory DNA Oligonucleotides on Experimental Colitis
Daniel Rachmilewitz, Fanny Karmeli, Leonor Leider-Trejo, Kenji Takabayashi, Tomoko Hayashi, and Eyal Raz
Part IX. Safety Considerations
CpG ODN: Safety Considerations
Daniela Verthelyi and Dennis M. Klinman
Index
Immunostimulatory Sequences in Plasmid Vectors
Christina C. N. Wu, Chih Min Tang, Brian Crain, and Maripat Corr
Part V. Applications-Infectious Disease
Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B
Michael J. McCluskie, Risini D. Weeratna, and Heather L. Davis
Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine?
Sandip K. Datta, Anthony A. Horner, Kenji Takabayashi, and Eyal Raz
Immunoprotective Activity of CpG Oligonucleotides
Dennis M. Klinman, Ken J. Ishii, and Ihsan Gursel
Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection
Tomoko Hayashi, Christine H. Tran, Lucinda Beck, Savita Rao, and Antonino Cantanzaro
Part VI. Applications-Allergy
DNA-Based Immunotherapeutics for Allergic Disease
Anthony A. Horner and Eyal Raz
Immunostimulatory DNA for Allergic Asthma
Reid K. Ikeda, Kenji Takabayashi, and David Broide
CpG Oligodeoxynucleotides in Asthma
Kunihiko Kitagaki and Joel N. Kline
Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides
Andrea Keane-Myers and Chi-Chao Chan
Part VII. Applications-Cancer
CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma
Thomas L. Warren and George J. Weiner
Part VIII. Inflammation and Autoimmunity
The Antigenicity of Bacterial DNA
David S. Pisetsky
Inflammatogenic Properties of Immunostimulatory DNA Sequences
Andrej Tarkowski, L. Vincent Collins, Guo-Min Deng, and Leno Mölne
The Role of Immunostimulatory DNA Sequences in Arthritis
Sarah T.A. Roord, Arash Ronaghy, Berent J. Prakken, Kenji Takabayashi, and Dennis A. Carson
Effects of Immunostimulatory DNA Oligonucleotides on Experimental Colitis
Daniel Rachmilewitz, Fanny Karmeli, Leonor Leider-Trejo, Kenji Takabayashi, Tomoko Hayashi, and Eyal Raz
Part IX. Safety Considerations
CpG ODN: Safety Considerations
Daniela Verthelyi and Dennis M. Klinman
Index
... weniger
Bibliographische Angaben
- 2012, 2002, XVII, 408 Seiten, Maße: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: Eyal Raz
- Verlag: Springer, Berlin
- ISBN-10: 1468497286
- ISBN-13: 9781468497281
Sprache:
Englisch
Rezension zu „Microbial DNA and Host Immunity “
"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News"This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journal
Pressezitat
"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News"This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journal
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