Modelling Parasite Transmission and Control

Part 1. Modelling Parasite Transmission1. Progress in Modelling Malaria TransmissionDavid L. Smith and Nick RuktanonchaiModelling Malaria Transmission, a Historical IntroductionComplexity, Parsimony and Robust Descriptions of TransmissionTransmission Intensity and Its EstimationsPreferential Biting and Uneven ExposureImmunity and the Infectious ReservoirMalaria Transmission in Real PopulationsConclusion2. Vector Transmission Heterogeneity and the Populat ion Dynamics and Control of Lymphatic FilariasisEdwin Michael and Manoj GambhirAbstractIntroductionLymphatic Filariasis Disease and Parasite Life CycleMosquito Vectors of Lymphatic FilariasisVector-Parasite Infection RelationshipsQuantifying the Mf-L3 Functional Response in Vector PopulationsDerivation of Vector-Specific Models of Lymphatic Filariasis TransmissionImpact of Vector-Specific Infection Processes on Parasite System Stability,Persistence and ExtinctionImpact of Vector-Specific Infection Processes on Age Patterns of InfectionThe Impact of Vector Genus on the Dynamics of Filariasis ControlConclusion3. Modelling Multi?Species Parasite TransmissionAndrea PuglieseAbstractIntroductionStructure and Parameters of ModelsThe Model without Direct InteractionsCompetition among ParasitesNormal ApproximationsCompetition and Host HeterogeneityConclusion4. Metap opulat ion Models in Tick?Borne Disease Transmission ModellingHolly Gaff and Elsa SchaeferAbstractIntroductionMethodsVariations within PatchesPatch ConnectivityThe Surrounding EnvironmentBoundary EffectsConclusion5. Modelling Stochastic Transmission Processes in Helminth InfectionsStephen J. CornellAbstractIntroductionInfection in a Single HostInfection among Multiple HostsConclusion6. Modelling Environmenta lly?Mediat ed Infectious Diseases of Humans: Transmission Dynamics of Schistosomiasis in ChinaJustin RemaisAbstractIntroductionModelling Schistosome TransmissionModel ParametersEnvironmentalDataModel DynamicsModelling Spatial ConnectivityExtending the

EDWIN MICHAEL is currently a Senior Lecturer in infectious disease epidemiology at Imperial College London, UK, with a research focus on modelling the transmission and control of tropical parasitic and infectious diseases. His main interest lies in developing a system dynamics approach to gaining a better understanding of parasite transmission, immunology, genetics and economics, in order to develop integrated mathematical models of pathogen transmission as a tool for aiding the rational design, monitoring and evaluation of large-scale intervention programmes, ranging from vector control, chemotherapy to vaccinations. He has worked extensively in Africa (primarily East Africa), India, Vietnam and Papua New Guinea, particularly over the past decade (in partnership with international (WHO, World Bank) and national institutions), in translating research on disease population biology, spatial dynamics and public health decision-making for developing reliable model-based spatial decision support tools to aid the design, surveillance and evaluation of ecologically resilient and sustainable intervention programmes against parasitic diseases of major public health importance in developing countries. His current interest is in extending this work to developing integrated ecological, economic and social systems approaches for investigating interactions between climate change, ecosystem dynamics and the socio-ecology of disease transmission in vulnerable communities.

ROBERT C. SPEAR is an engineer by training, having received the BS and MS degrees in Engineering Science and Mechanical Engineering, respectively, from the University of California at Berkeley and the PhD degree in Control Engineering from Cambridge University in 1968. After several years in the aerospace industry his interests turned to environmental issues and he returned to Berkeley in 1970 to take up a post-doctoral position in this field in the School of Public Health. He was appointed to a faculty