Modified Nucleosides in Biochemistry, Biotechnology and Medicine.Vol.1
(Sprache: Englisch)
This one-stop reference for every scientist working in the field covers more than 25 compound classes. The only comprehensive overview on the field addresses biochemical aspects and applications as well as compounds with therapeutic potential.
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This one-stop reference for every scientist working in the field covers more than 25 compound classes. The only comprehensive overview on the field addresses biochemical aspects and applications as well as compounds with therapeutic potential.
Klappentext zu „Modified Nucleosides in Biochemistry, Biotechnology and Medicine.Vol.1 “
Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances.The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs.Essential reading for every scientist working in this area.
Jeder drfte Nukleoside als Bausteine der Nukleinsuren (z.B. DNA oder RNA) kennen. Sie haben aber auch noch andere Funktionen innerhalb einer Zelle. Sie lassen sich gut chemisch modifizieren, sodass in den letzten Jahren eine Reihe modifizierter Nachbildungen von natrlich vorkommenden Nukleosiden entwickelt wurden - als Enzymhemmstoffe, biochemische Proben oder zytotoxische Verbindungen. In den letzten fnf Jahren gab es einen Durchbruch im klinischen Einsatz solcher Verbindungen - in der Krebsbekmpfung. Das Buch bietet Wissenschaftlern, die im Bereich der modifizierten Nukleoside ttig sind, alles Wesentlich zum Thema. Alle relevanten Verbindungsklassen werden vom Autorenteam behandelt. Im ersten Teil geht es um die Verbindungen, die hauptschlich Anwendung finden in Biochemie und Molekularbiologie. Der zweite Teil widmet sich den Verbindungen, die schon jetzt oder potenziell wichtig sind fr die Krankheitsbehandlung. Etliche jngst entwickelte Verbindungen haben in den letzten Jahren Marktreife erreicht (z. B. in der Antitumorbehandlung). Insgesamt werden mehr als 25 Verbindungen und Verbindungsklassen detailliert beschrieben.
Der Autor hat mittlerweile fast 500 Beitrge fr wissenschaftliche Zeitschriften und Bcher geliefert und ist Herausgeber der 'Current Protocols in Nucleic Acid Chemistry', die ebenfalls bei Wiley erscheinen.
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Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances.
The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs.
Essential reading for every scientist working in this area.
Der Autor hat mittlerweile fast 500 Beitrge fr wissenschaftliche Zeitschriften und Bcher geliefert und ist Herausgeber der 'Current Protocols in Nucleic Acid Chemistry', die ebenfalls bei Wiley erscheinen.
----------------------------------------
Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances.
The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs.
Essential reading for every scientist working in this area.
Inhaltsverzeichnis zu „Modified Nucleosides in Biochemistry, Biotechnology and Medicine.Vol.1 “
BIOCHEMISTRY AND BIOPHYSICSInvestigations on Fluorine-labeled Ribonucleic Acids by 19F-NMR Spectroscopy8-Oxo-7,8-dihydro-2'-deoxyguanosine, a major DNA oxidation productModified DNA Bases: Probing Base Pair Recognition by Polymerases2'-Deoxyribose Modified Nucleoside Triphosphates and their Recognition by DNA PolymerasesPyrimidine Dimers: UV-induced DNA DamageLocked Nucleic Acids: Properties, Applications and PerspectivesStudies on the synthesis and properties of oligonucleotides incorporating modified nucleobases capable for the formation of Watson and Crick type base pairsThe Properties of 4'-ThionucleosidesS-Adenosyl-L-methionine and related compoundsBIOTECHNOLOGY5-Subsituted nucleosides in biochemistry and biotechnologyUniversal base analogues and their applications to biotechnologyMEDICINAL CHEMISTRYThe Properties of Locked Methanocarba Nucleosides in Biochemistry, Biotechnology and Medicinal ChemistrySynthesis, chemical properties and biological activities of cyclic bis(3'-5')diguanylic acid (c-di-GMP) and its analoguesSiderophore Biosynthesis InhibitorsSynthesis and Biological Activity of Selected Carbocyclic Nucleosides4'-C-Ethynyl-2'-deoxynucleosidesModified nucleosides as Selective Modulators of Adenosine Receptors for Therapeutic UseThe Design of Forodesine HCl and Other Purine Nucleoside Phosphorylase InhibitorsFormycin and Analogues: Purine Nucleoside Phosphorylase Inhibitors and their Potential Application in Immunosuppression and cancer1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd)Syntheses and Biological Activity of Neplanocin and AnaloguesClitocine and Its AnalogsANTITUMORALS AND ANTIVIRALSCapecitabine Preclinical Studies: From Discovery to Translational ResearchTenofovir and Adefovir as Antiviral AgentsClofarabine: Design to Approval
Autoren-Porträt
Piet Herdewijn is full professor of Pharmaceutical Sciences at the University of Leuven (Belgium). He holds a Ph.D. from the same institution, having worked as a post-doctoral researcher and assistant professor at the universities of Konstanz (Germany) and Ghent (Belgium) in between. He is a member of the Belgian Academy of Medicine, representing Chemistry, and a founding member of the International Society of Nucleosides, Nucleotides, and Nucleic Acids.Apart from having close to 500 contributions to scientific journals and books to his credit, he is an editor of the Current Protocols in Nucleic Acid Chemistry, also published by Wiley.
Bibliographische Angaben
- 2008, XXVI, 658 Seiten, 30 farbige Abbildungen, 328 Schwarz-Weiß-Abbildungen, Maße: 18,2 x 24,6 cm, Gebunden, Englisch
- Herausgegeben: Piet Herdewijn
- Verlag: Wiley-VCH
- ISBN-10: 3527318208
- ISBN-13: 9783527318209
- Erscheinungsdatum: 13.08.2008
Sprache:
Englisch
Rezension zu „Modified Nucleosides in Biochemistry, Biotechnology and Medicine.Vol.1 “
"The overall quality of the book is high and it will be an important resource to the modified nucleoside community. The book contains a number of excellent individual chapters that offer a new and interesting perspective on the field ... I believe that this book will be an excellent resource for synthesis chemists looking for summaries of existing strategies to generate a wide range of modified nucleosides. Along that line, the more clinically based chapters provide good summaries of the biological activities of the modified nucleotides. There is a nice balance of older and newer literature that should be of use to established as well as novice researchers, and most of the chapters are well referenced and up-to-date. I would certainly recommend this book to anyone interested in the bioorganic and medicinal chemistry of modified nucleosides and nucleic acids." ( Journal of the American Chemical Society , March 25, 2009) "Herdewijn, with the help of the contributing authors, has assembled a fine collection of well-written and well-edited reviews. This book will be indispensable to students and researchers." ( ChemBioChem , January 2009)
Pressezitat
"The overall quality of the book is high and it will be an important resource to the modified nucleoside community. The book contains a number of excellent individual chapters that offer a new and interesting perspective on the field ... I believe that this book will be an excellent resource for synthesis chemists looking for summaries of existing strategies to generate a wide range of modified nucleosides. Along that line, the more clinically based chapters provide good summaries of the biological activities of the modified nucleotides. There is a nice balance of older and newer literature that should be of use to established as well as novice researchers, and most of the chapters are well referenced and up-to-date. I would certainly recommend this book to anyone interested in the bioorganic and medicinal chemistry of modified nucleosides and nucleic acids." ( Journal of the American Chemical Society , March 25, 2009)"Herdewijn, with the help of the contributing authors, has assembled a fine collection of well-written and well-edited reviews. This book will be indispensable to students and researchers." ( ChemBioChem , January 2009)
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