Molecular and Quantum Pharmacology

Introductory Remarks on Pharmacological Receptors.- The Adventures of a Quantum-Chemist in the Kingdom of Pharmacophores.- Quantitative Structure-Activity Relationships. An Approach to Drug Design.- Imidazole Tautomerism of Histamine Derivatives.- The Conformation of Histamine, 5-Hydroxytryptamine and Some Related Derivatives in Aqueous Solution.- Molecular Orbital Calculations on Catecholamines; Theory and Experiment.- The Conformation of Catecholamines in Solution.- Molecular Factors and Activity in Psychopharmacologically Active Compounds.- An Approach to Possible Correlations Between Activity and Conformation in Some Classes of Psychotropic Drugs.- Studies of the Conformation in Solution of Molecules Related to Acetylcholine.- Solvent-Dependent Conformational Studies of Acetylcholine and Some Related Molecules.- Theoretical Studies of Solvent Effects on the Conformational Stability of Cholinergic Molecules.- Conformational Isomerism in Drug Action: Does the Free Energy of Binding Induce the Pharmacophoric Conformation of Semi-Rigid Muscarinic Agonists?.- Studies on the Cholinergic Receptor of Squid Optic Ganglia.- Stereochemical Similarities in Chemically Different Antiepileptic Drugs.- Molecular Orbital Calculations on Anti-Epileptic Compounds.- A Conformational Study of Antihistaminic Pheniramines in Solution.- NMR Studies of Solution Conformations of Physiologically Active Amino-Acids.- The Molecular Structures of the Phenothiazine Derivatives, Chlorpromazine, Thiethylperazine and Thioridazine, and a Discussion of the Mechanism of Action.- Conformational Studies on Hormonal Peptides Using Nuclear Magnetic Resonance Spectroscopy.- Conformational Studies of Cyclotetradepsipeptides and Analogues Related to Serratamolide.- Ab Initio Calculations on Large Molecules Using Molecular Fragments. Initial Studies on Prostaglandin PGF1?.- A Molecular Orbital Study of Some Substituted Benzyl Propynyl Ethers as Insecticide Synergists.- The Role of Conformation and