Molecular Diagnostics for Melanoma
Methods and Protocols
(Sprache: Englisch)
In Molecular Diagnostics for Melanoma: Methods and Protocols, expert researchers and clinicians in the field of melanoma provide updated information on biomarkers and assays for diagnosis, prognosis, and assays predicting response to treatment for routine...
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Produktinformationen zu „Molecular Diagnostics for Melanoma “
In Molecular Diagnostics for Melanoma: Methods and Protocols, expert researchers and clinicians in the field of melanoma provide updated information on biomarkers and assays for diagnosis, prognosis, and assays predicting response to treatment for routine testing. The focus of the volume is on biomarkers with established clinical validity rather than those on early discovery stage. With additional in-depth discussion of the molecular biology and pathology of melanoma, treatment options in adjuvant and metastatic setting, and implications of biomarker testing for clinical management of melanoma patients.
Written in the highly successful Methods in Molecular Biology series format, chapters include extensive introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Molecular Diagnostics for Melanoma: Methods and Protocols seeks to provide both clinicians and scientists with technical information and extensive background information on the wide ranging approaches available in the field of diagnostics of melanoma.
Written in the highly successful Methods in Molecular Biology series format, chapters include extensive introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Molecular Diagnostics for Melanoma: Methods and Protocols seeks to provide both clinicians and scientists with technical information and extensive background information on the wide ranging approaches available in the field of diagnostics of melanoma.
Klappentext zu „Molecular Diagnostics for Melanoma “
In Molecular Diagnostics for Melanoma: Methods and Protocols, expert researchers and clinicians in the field of melanoma provide updated information on biomarkers and assays for diagnosis, prognosis, and assays predicting response to treatment for routine testing. The focus of the volume is on biomarkers with established clinical validity rather than those on early discovery stage. With additional in-depth discussion of the molecular biology and pathology of melanoma, treatment options in adjuvant and metastatic setting, and implications of biomarker testing for clinical management of melanoma patients.Written in the highly successful Methods in Molecular Biology series format, chapters include extensive introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Molecular Diagnostics for Melanoma: Methods and Protocols seeks to provide both clinicians and scientists with technical information and extensive background information on the wide ranging approaches available in the field of diagnostics of melanoma.
Inhaltsverzeichnis zu „Molecular Diagnostics for Melanoma “
Part I. Clinical Challenges and Current Status of Treatment of Melanoma1. Novel Insights/translational Implication from the Emerging Biology of Melanoma, Antoni Ribas
2. Emerging Clinical Issues in Melanoma in the Molecularly Targeted Era, Ryan J. Sullivan and Michael B. Atkins
3. Integrating Molecular Biomarkers Into Current Clinical Management In Melanoma, Ragini Kudchadkar, Geoffrey Gibney, and Vernon K. Sondak, Part II. Biomarkers for Prediction of Response and Resistance to Treatment
4. Advances in Adjuvant Therapy: Potential for Prognostic and Predictive Biomarkers, Diwakar Davar, Ahmad A. Tarhini, Helen Gogas, and John M. Kirkwood
5. Immunologic Monitoring of Cancer Vaccine Trials Using the ELISPOT Assay, Lisa H. Butterfield and Mary Jo Buffo
6. Markers for Anti-Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Therapy in Melanoma, Michael A. Postow, Jianda Yuan, Shigehisa Kitano, Alexander M. Lesokhin, and Jedd D. Wolchok
7. Marker Utility for Combination Therapy, Ester Simeone, Antonio M. Grimaldi, and Paolo A. Ascierto
8. Assaying for BRAF V600E in Tissue and Blood in Melanoma, David J. Panka, James W. Mier, and Ryan J. Sullivan
9. Selecting Patients for KIT Inhibition in Melanoma, Richard D. Carvajal, Omid Hamid, and Cristina R. Antonescu
10. Detecting Mechanisms of Acquired BRAF inhibitor Resistance in Melanoma, Roger Lo and Hubing Shi
11. Current Status of Diagnostic and Prognostic Markers in Melanoma, Danielle Levine and David E. Fisher
12. Chromosomal Copy Number Analysis in Melanoma Diagnostics, Jeffrey P. North, Swapna Vemula, and Boris C. Bastian
13. Construction and Analysis of Multi-Parameter Prognostic Models for Melanoma Outcome, Bonnie E. Gould Rothberg and David L. Rimm
14. Immunohistochemical Diagnostic and Prognostic Markers for Melanoma, Mehdi Nosrati and Mohammed Kashani-Sabet
15. Lymphatic Invasion as a Prognostic Biomarker in Primary Cutaneous Melanoma, Xiaowei Xu, Phyllis A. Gimotty, DuPont Guerry, Giorgos Karakousis, and David
... mehr
E. Elder
16. Tumor Infiltrating Lymphocytes and Their Significance in Melanoma Prognosis, Tobias Schatton, Richard A. Scolyer, John F. Thompson, and Martin C. Mihm, Jr
17. Pathological Staging of Melanoma, David E. Elder
18. Genotyping of Human Leukocyte Antigen (HLA) Ancestral Haplotypes as Prognostic Marker in Cancer Using PCR Analysis, Lisa Villabona, Emilia Andersson, Maddalena Marchesi, and Giuseppe V. Masucci
19. B7-H Abnormalities in Melanoma and Clinical Relevance, Barbara Seliger
20. Melanoma Susceptibility Genes and Risk Assessment, Alexander Marxuka-Alcalá, Michele Jacobs Gabree, and Hensin Tsao, Part IV. Uveal Melanoma
21. Clinical, Pathologic, and Imaging Features, and Biological Markers of Uveal Melanoma, Hans E. Grossniklaus and Alia B. Rashid
22. A Prognostic Test to Predict Risk of Metastasis in Uveal Melanoma Based on a 15-Gene Expression Profile, J. William Harbour
23. Molecular Karyotyping for Detection of Prognostic Markers in Fine Needle Aspirate Biopsy Samples of Uveal Melanoma, Arupa Ganguly, Jennifer Richards-Yutz, and Kathryn G. Ewens, Part V. Emerging Markers/Targets in Melanoma
24. ERBB4 Mutation Analysis: Emerging Molecular Target for Melanoma Treatment, Christopher Lau, Keith J. Killian, Yardena Samuels, and Udo Rudloff
25. Epigenetic Markers of Prognosis in Melanoma, Luca Sigalotti, Elisabetta Fratta, Giulia Parisi, Sandra Coral, and Michele Maio
26. Isolation of Melanoma Cell Subpopulations Using Negative Selection, Ana Slipicevic, Rajasekharan Somasundaram, Katrin Sproesser, and Meenhard Herlyn
27. Circulating Tumor Cells as Prognostic Biomarkers in Cutaneous Melanoma Patients, Eiji Kiyohara, Keisuke Hata, Stella Lam, and Dave S. B. Hoon
28. Detection of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Melanoma, Yangyang Wang, Francesco Sabbatino, Xinhui Wang, and Soldano Ferrone
29. Targeting Damage Associated Molecular Pattern Molecules (DAMPs) and DAMP Receptors in Melanoma, Brian A. Boone and Michael T. Lotze
30. The Clinical Use of PET/CT in the Evaluation of Melanoma Khun Visith Keu and Andrei H. Iagaru, Part VI. Emerging Technologies for Marker Validation
31. Immune System Functional Pathway Analysis Using Single Cell Network Profiling (SCNP): A Novel Tool in Cancer Immunotherapy, Alessandra Cesano
32. Quantitative and Spatial Image Analysis of Tumor and Draining Lymph Nodes Using Immunohistochemistry and High Resolution Multispectral Imaging to Predict Metastasis, Kim R.M. Blenman and Peter P. Lee
33. COLD-PCR Enriches Low-Level Variant DNA Sequences and Increases the Sensitivity of Genetic Testing, Elena Castellanos-Rizaldos, Coren A. Milbury, Minakshi Guha, and G. Mike Makrigiorgos
34. Isolation of Circulating MicroRNAs from Microvesicles found in Human Plasma, John F. Quackenbush, Pamela B. Cassidy, Lawrence M. Pfeffer, Kenneth M. Boucher, Jason E. Hawkes, Susan R. Pfeffer, Levy Kopelovich, and Sancy A. Leachman
35. Detection of Circulating Tumor Cells by Photoacustic Flowmetry, Ryan M. Weight and James A. Viator, Part VII. Marker Validation Requirements for Clinical Applicability
36. Statistical Design and Evaluation of Biomarker Studies, Kevin K. Dobbin
37. Tissue Resources for Clinical Use and Marker Studies in Melanoma, Jonathan L. Curry, Michael A. Davies, Tiffany L. Calderone, Katherine Nathanson, Victor G. Prieto, and Jeffrey Gershenwald
16. Tumor Infiltrating Lymphocytes and Their Significance in Melanoma Prognosis, Tobias Schatton, Richard A. Scolyer, John F. Thompson, and Martin C. Mihm, Jr
17. Pathological Staging of Melanoma, David E. Elder
18. Genotyping of Human Leukocyte Antigen (HLA) Ancestral Haplotypes as Prognostic Marker in Cancer Using PCR Analysis, Lisa Villabona, Emilia Andersson, Maddalena Marchesi, and Giuseppe V. Masucci
19. B7-H Abnormalities in Melanoma and Clinical Relevance, Barbara Seliger
20. Melanoma Susceptibility Genes and Risk Assessment, Alexander Marxuka-Alcalá, Michele Jacobs Gabree, and Hensin Tsao, Part IV. Uveal Melanoma
21. Clinical, Pathologic, and Imaging Features, and Biological Markers of Uveal Melanoma, Hans E. Grossniklaus and Alia B. Rashid
22. A Prognostic Test to Predict Risk of Metastasis in Uveal Melanoma Based on a 15-Gene Expression Profile, J. William Harbour
23. Molecular Karyotyping for Detection of Prognostic Markers in Fine Needle Aspirate Biopsy Samples of Uveal Melanoma, Arupa Ganguly, Jennifer Richards-Yutz, and Kathryn G. Ewens, Part V. Emerging Markers/Targets in Melanoma
24. ERBB4 Mutation Analysis: Emerging Molecular Target for Melanoma Treatment, Christopher Lau, Keith J. Killian, Yardena Samuels, and Udo Rudloff
25. Epigenetic Markers of Prognosis in Melanoma, Luca Sigalotti, Elisabetta Fratta, Giulia Parisi, Sandra Coral, and Michele Maio
26. Isolation of Melanoma Cell Subpopulations Using Negative Selection, Ana Slipicevic, Rajasekharan Somasundaram, Katrin Sproesser, and Meenhard Herlyn
27. Circulating Tumor Cells as Prognostic Biomarkers in Cutaneous Melanoma Patients, Eiji Kiyohara, Keisuke Hata, Stella Lam, and Dave S. B. Hoon
28. Detection of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Melanoma, Yangyang Wang, Francesco Sabbatino, Xinhui Wang, and Soldano Ferrone
29. Targeting Damage Associated Molecular Pattern Molecules (DAMPs) and DAMP Receptors in Melanoma, Brian A. Boone and Michael T. Lotze
30. The Clinical Use of PET/CT in the Evaluation of Melanoma Khun Visith Keu and Andrei H. Iagaru, Part VI. Emerging Technologies for Marker Validation
31. Immune System Functional Pathway Analysis Using Single Cell Network Profiling (SCNP): A Novel Tool in Cancer Immunotherapy, Alessandra Cesano
32. Quantitative and Spatial Image Analysis of Tumor and Draining Lymph Nodes Using Immunohistochemistry and High Resolution Multispectral Imaging to Predict Metastasis, Kim R.M. Blenman and Peter P. Lee
33. COLD-PCR Enriches Low-Level Variant DNA Sequences and Increases the Sensitivity of Genetic Testing, Elena Castellanos-Rizaldos, Coren A. Milbury, Minakshi Guha, and G. Mike Makrigiorgos
34. Isolation of Circulating MicroRNAs from Microvesicles found in Human Plasma, John F. Quackenbush, Pamela B. Cassidy, Lawrence M. Pfeffer, Kenneth M. Boucher, Jason E. Hawkes, Susan R. Pfeffer, Levy Kopelovich, and Sancy A. Leachman
35. Detection of Circulating Tumor Cells by Photoacustic Flowmetry, Ryan M. Weight and James A. Viator, Part VII. Marker Validation Requirements for Clinical Applicability
36. Statistical Design and Evaluation of Biomarker Studies, Kevin K. Dobbin
37. Tissue Resources for Clinical Use and Marker Studies in Melanoma, Jonathan L. Curry, Michael A. Davies, Tiffany L. Calderone, Katherine Nathanson, Victor G. Prieto, and Jeffrey Gershenwald
... weniger
Bibliographische Angaben
- 2013, Repr. d. Ausg. v. 2013, XXIII, 712 Seiten, 94 farbige Abbildungen, Maße: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Magdalena Thurin, Francesco M. Marincola
- Verlag: Springer, Berlin
- ISBN-10: 1627037268
- ISBN-13: 9781627037266
- Erscheinungsdatum: 09.12.2013
Sprache:
Englisch
Pressezitat
From the reviews:"This substantive book is a compilation of focused reviews and laboratory protocols for biomarkers associated with melanoma and related targeted therapies. ... This would be useful to anyone interested in melanoma, from clinicians wanting an update on promising molecular targets for melanoma treatment to researchers wanting detailed protocols for diagnostic or treatment monitoring assays. ... If you are working in melanoma research or treating patients with melanoma, you will very much appreciate this book." (Valerie L. Ng, Doody's Book Reviews, March, 2014)
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