Molecular Diagnostics
For the Clinical Laboratorian
(Sprache: Englisch)
This updated and expanded tutorial guide to molecular diagnostic techniques takes advantage of many new molecular technologies to include both improved traditional methods and totally new methods, some not yet in routine use. The authors offer cutting-edge...
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Produktinformationen zu „Molecular Diagnostics “
This updated and expanded tutorial guide to molecular diagnostic techniques takes advantage of many new molecular technologies to include both improved traditional methods and totally new methods, some not yet in routine use. The authors offer cutting-edge molecular diagnostics for genetic disease, human cancers, infectious diseases, and identity testing, as well as new insights into the question of quality assurance in the molecular diagnostics laboratory. Additional chapters address other technologies found in the clinical laboratory that complementary to molecular diagnostic technologies and discuss genetic counseling and the ethical and social issues involved with nucleic acid testing.
Klappentext zu „Molecular Diagnostics “
Taking advantage of the many major advances that have occurred since their groundbreaking first edition was published, William B. Coleman and Gregory J. Tsongalis have updated and expanded their highly praised tutorial guide to molecular diagnostic techniques to include not only improved traditional methods, but also totally new molecular technologies, some not yet in routine use. The authors offer cutting-edge molecular diagnostics for genetic disease, human cancers, infectious diseases, and identity testing, as well as new insights into the question of quality assurance in the molecular diagnostics laboratory. Additional chapters address other technologies found in the clinical laboratory that are complementary to molecular diagnostic methodologies, and also discuss genetic counseling and the ethical and social issues involved with nucleic acid testing. Authoritative and state-of-the-art, Molecular Diagnostics: For the Clinical Laboratorian, 2nd Edition is the essential textbook of choice for anyone working in molecular diagnostics and who wants to remain current with this rapidly changing field.
Taking advantage of the many major advances that have occurred since their groundbreaking first edition was published, William B. Coleman and Gregory J. Tsongalis have updated and expanded their highly praised tutorial guide to molecular diagnostic techniques to include not only improved traditional methods, but also totally new molecular technologies, some not yet in routine use. The authors offer cutting-edge molecular diagnostics for genetic disease, human cancers, infectious diseases, and identity testing, as well as new insights into the question of quality assurance in the molecular diagnostics laboratory. Additional chapters address other technologies found in the clinical laboratory that are complementary to molecular diagnostic methodologies, and also discuss genetic counseling and the ethical and social issues involved with nucleic acid testing.
Authoritative and state-of-the-art, Molecular Diagnostics: For the Clinical Laboratorian, 2nd Edition is the essential textbook of choice for anyone working in molecular diagnostics and who wants to remain current with this rapidly changing field.
Authoritative and state-of-the-art, Molecular Diagnostics: For the Clinical Laboratorian, 2nd Edition is the essential textbook of choice for anyone working in molecular diagnostics and who wants to remain current with this rapidly changing field.
Inhaltsverzeichnis zu „Molecular Diagnostics “
An Historical Perspective on the Clinical Diagnostic Laboratory.- Basic Molecular Biology.- An Overview of Nucleic Acid Chemistry, Structure, and Function.- Extraction of Nucleic Acids.- Nucleic Acid Blotting Techniques.- The Polymerase Chain Reaction.- Bioinformatics.- Molecular Diagnostic Technologies.- PCR-Based Methods for Mutation Detection.- Alternative Methods for Amplified Nucleic Acid Testing.- Electrophoretic Methods for Mutation Detection and DNA Sequencing.- Single-Nucleotide Polymorphisms.- Microarray Approaches to Gene Expression Analysis.- Methods for Analysis of DNA Methylation.- Other Clinical Diagnostic Technologies.- Flow Cytometry.- Medical Cytogenetics.- Fluorescence In Situ Hybridization.- Immunohistochemistry.- Laser Capture Microdissection.- Quality Assurance in the Molecular Diagnostics Laboratory.- Framework for Quality Assurance in Molecular Diagnostics.- Verification of Molecular Assays.- Standards and Standardization of Molecular Diagnostics.- Laboratory-Developed Tests in Molecular Diagnostics.- Applications of Molecular Diagnostics for Genetic Diseases.- An Overview of Molecular Genetics.- Genetic Basis of Neurologic and Neuromuscular Diseases.- Molecular Mechanisms of Endocrine Disorders.- Molecular Pathogenesis of Cardiovascular Disease.- Molecular Diagnostics in Coagulation.- Cystic Fibrosis.- Prenatal Genotyping for Identification of Fetuses at Risk for Immune Cytopenic Disorders.- Personalized Medicine.- Applications of Molecular Diagnostics for Human Cancers.- Molecular Pathogenesis of Human Cancer.- Application of Molecular Diagnostics to Hereditary Nonpolyposis Colorectal Cancer.- Molecular Genetic Applications to the Diagnosis of Lymphoma.- Molecular Genetic Abnormalities in Acute and Chronic Leukemias.- Applications of MolecularDiagnostics for Infectious Diseases.- Molecular Testing for Chlamydia trachomatis and Neisseria gonorrhoeae.- Human Papillomavirus.- Molecular Diagnostics for HIV-1.- Hepatitis C.- Cytomegalovirus.-
... mehr
Applications of Molecular Diagnostics for Identity-Based Testing.- HLA Typing Using Molecular Methods.- Molecular Analysis for Forensic Casework and Parentage Testing.- Molecular Assessment of Bone Marrow Transplant Engraftment.- Use of DNA-Based Identity Testing for Specimen Identification.- Issues for the Clinical Molecular Pathology Laboratory.- Genetic Counseling Considerations in Molecular Diagnosis.- Ethical, Social, and Legal Issues Related to Molecular Genetic Testing.
... weniger
Bibliographische Angaben
- Autor: William B. Coleman
- 2005, 2. Aufl., XVIII, 567 Seiten, Maße: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: William B. Coleman, Gregory J. Tsongalis
- Verlag: Springer, Berlin
- ISBN-10: 1588293564
- ISBN-13: 9781588293565
- Erscheinungsdatum: 16.04.2012
Sprache:
Englisch
Rezension zu „Molecular Diagnostics “
"This is a great book to have handy for ready reference in this rapidly evolving field. While the reader may not use this reference daily, there is no question that it will be needed for those occasions when such testing is ordered and a clinical consultation between the clinical laboratory and the healthcare provider is necessary." - Doody's Health Sciences Book Review Journal"...the textbook of choice for anyone working in molecular diagnostics who wants to remain current with this rapidly changing field. -Clinical Laboratory InternationalFrom Reviews of the First Edition..."...a very good introduction to the basic elements of molecular pathology...a clear, enjoyable read...an excellent discussion of methods." -Clinical Chemistry "...highly recommended...for those interested in clinical molecular diagnosis...will satisfy those who are more expert in certain areas of molecular diagnosis, but who have been unable to keep up with the wide range of recent advances in molecular diagnosis." -American Journal of Clinical Pathology"...gives a good theoretical background for those with little experience in this field. It is readable, comprehensive, and...up-to-date." -Journal of Clinical Pathology"...well written, comprehensive...should bring even the reader with limited background knowledge up to speed on what is a rapidly progressing field." -Trends in Molecular Medicine"...a timely and highly relevant book that will serve as a valuable resource to those practicing molecular diagnostics from the bench, as well as to basic and clinical scientists..." -Endocrine News
Pressezitat
"This is a great book to have handy for ready reference in this rapidly evolving field. While the reader may not use this reference daily, there is no question that it will be needed for those occasions when such testing is ordered and a clinical consultation between the clinical laboratory and the healthcare provider is necessary." - Doody's Health Sciences Book Review Journal"...the textbook of choice for anyone working in molecular diagnostics who wants to remain current with this rapidly changing field. -Clinical Laboratory International
From Reviews of the First Edition...
"...a very good introduction to the basic elements of molecular pathology...a clear, enjoyable read...an excellent discussion of methods." -Clinical Chemistry
"...highly recommended...for those interested in clinical molecular diagnosis...will satisfy those who are more expert in certain areas of molecular diagnosis, but who have been unable to keep up with the wide range of recent advances in molecular diagnosis." -American Journal of Clinical Pathology
"...gives a good theoretical background for those with little experience in this field. It is readable, comprehensive, and...up-to-date." -Journal of Clinical Pathology
"...well written, comprehensive...should bring even the reader with limited background knowledge up to speed on what is a rapidly progressing field." -Trends in Molecular Medicine
"...a timely and highly relevant book that will serve as a valuable resource to those practicing molecular diagnostics from the bench, as well as to basic and clinical scientists..." -Endocrine News
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