Molecular Immunotoxicology

PrefaceTHE EVOLUTION OF IMMUNOTOXICOLOGYIntroductionImmune-Mediated Environmental Lung DiseasesImmunotoxic Drug ReactionsAutoimmunityImmunosuppressionAllergic Contact Dermatitis (ACD)SummaryOVERVIEW OF THE MECHANISMS UNDERLYING CHEMICAL-INDUCED IMMUNOTOXICOLOGYIntroductionMechanisms of ImmunotoxicityConclusionsUSE OF TOXICOGENOMICS IN IMMUNOTOXICOLOGYIntroductionToxicogenomicsBioinformatics and Data AnalysisMultiple Omic Approaches in the Evaluation of Immunosuppressive CompoundsSummary and ConclusionsBREAKDOWN OF THE MOLECULAR PROCESSES DRIVING THE ADVERSE OUTCOME PATHWAYS (AOPs) OF SKIN AND RESPIRATORY SENSITIZATION INDUCTION IN HUMANS EXPOSED TO XENOBIOTICS AND PROTEINSIntroductionThe AOP for Skin SensitizationThe Molecular Processes in the MOA for Sensitization InductionSummaryCHEMICAL ALLERGEN-INDUCED SKIN CELL ACTIVATIONIntroductionBreaching in BarriersRole of the Extracellular Matrix in Skin InflammationCytoprotective Responses and Skin InflammationSkin Dendritic Cells - Tolerance versus ImmunityDC Activation and MigrationThe Role of Danger SignalsInappropriate/Compromised DC ActivationT-Cell Activation and Immune RegulationAllergic Contact Dermatitis as a (Sterile) "Infection" - ImplicationsTHE ARYL HYDROCARBON RECEPTOR (AhR) AS A MEDIATOR OF ADVERSE IMMUNE REACTIONSIntroductionThe Arylhydrocarbon Receptor - a Sensor of Chemicals and a Link to Our Chemical EnvironmentImmunotoxicity of TCDD, the Paradigm Ligand of AhRAhR-Deficient Animal Models to Study AhR Function in the Immune SystemConcluding RemarksIMMUNOTOXICOLOGICAL EFFECTS OF PHARMACEUTICALS ON SIGNAL TRANSDUCTION IN INNATE AND ADAPTIVE IMMUNITYIntroductionDrug Affecting Signal Transduction in Innate ImmunityDrug affecting Signal Transduction in Adaptive ImmunityPROMISES AND CHALLENGES WITH IMMUNOMODULATORY BIOLOGICSIntroductionAdaptive Immunity in the Control of TumorsRecent Developments in Oncology Immunotherapy - Case ExamplesConclusionsTHE NONCLINICAL EVALUATION OF BIOTECHNOLOGY-DERIVED

Emanuela Corsini is associate professor of Toxicology at the School of Pharmacy of the University of Milan (Italy), where she heads the Laboratory of Immunotoxicology and Immunopharmacology. She obtained her PhD in Food and Environmental Toxicology in 1993 at the University of Milan. Dr. Corsini's research program encompasses distinct areas of immunotoxicology, including the understanding of the molecular mechanisms of action of immunotoxic/immunomodulatory compounds on both innate and adaptive immunity. She is active in numerous scientific and professional organizations, serves on several editorial boards of Toxicology journals. From 2009-2013 she was Member of EUROTOX Education Sub Committee, from 2005-2011 she was the Chair of the Immunotoxicology and Chemical Specialty Section at EUROTOX, and from 2010 she is one of the Director of the IUTOX Executive Committee.Henk van Loveren did his PhD (tumor immunology) at Utrecht University in 1981 and was post-doctoral fellow (immunology) at Yale University, New Haven CT, USA in 1982. Since 1984, he is at the National Institute of Public Health and the Environment in Bilthoven, the Netherlands, where he has run the Immunotoxicology program and is now Senior Scientific Advisor to the Centre of Health Protection. In addition, he is also Professor of Immunotoxicology at Maastricht University in the Netherlands. His research has been devoted to the development of immunotoxicity testing, being performed in cell systems, in laboratory animals and clinical settings. Recent developments are the implementation of toxicogenomics in immunotoxicity testing. He has been member of several advisory committees, in addition to being director of the WHO Collaborating Centre for Immunotoxicology and Allergic Hypersensitivity. Prof. van Loveren was one of the founders of the Immunotoxicology and Chemical Specialty Section at EUROTOX and served as its president from 2000-2003. For his achievements, he got the Vos Career Achievement Award