Molecules and Medicine

PART I. INTRODUCTION

UNDERSTANDING STRUCTURAL DIAGRAMS OF ORGANIC MOLECULES

SOME COMMON MOLECULES

PROTEINS AND THREE-DIMENSIONAL PROTEIN STRUCTURE

SOME OF THE PROTEIN STRUCTURES THAT APPEAR IN THIS BOOK

PART II. INFLAMMATORY, CARDIOVASCULAR AND METABOLIC DISEASES

ANTI-INFLAMMATORY AGENTS
- Acetylsalicylic acid Aspirin)
- Naproxen (Aleve)
- How Do Anti-Inflammatory Drugs Work?
- Other Eicosanoids in Inflammation
- An Overview of Inflammation
- Celecoxib (Celebrex)
- Prednisone (Deltasone)
- Methotrexate (Trexall)
- Allopurinol (Zyloprim)

ANTIASTHMATICAND ANTIALLERGIC AGENTS
- Salmeterol (Serevent)
- Fluticasone Propionate (Flovent)
- Montelukast Sodium (Singulair)
- Tiotropium Bromide (Spiriva)
- Loratadine (Claritin)

TYPE2 DIABETES
- An Overview of Metabolic Syndrome

ANTIDIABETICAND CHOLESTEROL-LOWERING AGENTS
- Metformin (Glucophage)
- Glipizide (Glucotrol)
- Pioglitazone (Actos)
- Sitagliptin (Januvia)
- Atorvastatin (Lipitor)
- Ezetimibe (Zetia)

CARDIOVASCULARAGENTS
- Atenolol (Tenormin)
- Enalapril (Vasotec)
- Candesartan Cilexetil (Atacand)
- Aliskiren (Tekturna)
- Amlodipine (Norvasc)
- Nitroglycerin
- Clopidogrel Bisulfate (Plavix)
- Digoxin (Lanoxin)

RECEPTORSAND SIGNALING
- Information Flow into the Cell by Chemical Signaling

REFERENCES FOR PART II

PART III. REPRODUCTIVE MEDICINE
- Oral Contraceptives
- Testosterone
- Mifepristone (Mifeprex)
- Oxytocin (Oxytocin)
- Sildenafil (Viagra)
- OSTEOPOROSIS
- Some Aspects of Osteoporosis
- Alendronate (Fosamax)
- Calcitriol (Rocaltrol)
- Raloxifene (Evista)
- Teriparatide (Forteo)

GLAUCOMAAND ANTIULCER AGENTS
- Latanoprost (Xalatan)
- Ranitidine (Zantac)
- Omeprazole (Prilosec)

REFERENCESFOR PART III

PART IV. AUTOIMMUNE DISEASE AND ORGAN TRANSPLANT
- A Brief Survey of the Immune System

IMMUNOSUPPRESSIVEAGENTS
- Azathioprine (Imuran)
- Mycophenolate Mofetil (CellCept)
- Cyclosporin (Neoral)
- Tacrolimus (Prograf)
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E. J. Corey has been a Professor at Harvard University since 1959. He was educated at The Massachusetts Institute of Technology (1945-1950) and served as a faculty member at the University of Illinois from1951 to 1959. He is the 1990 Nobel Laureate in Chemistry, and the recipient of over seventy international awards and honorary degrees, including the U.S. National Medal of Science, the Japan Prize in Science, and the Priestley Medal of the American Chemical Society. He is amember of the U.S. National Academy of Sciences and the U.S. National Institute of Medicine. Professor Corey is the author of more than 1,000 publications and is one of the most cited authors in science.

Barbara Czakó completed undergraduate studies at the University of Debrecen, Hungary, where she worked with Dr. Sándor Berényi. She obtained a Master of Science degree at the University of Missouri-Columbia with Professor Shon R. Pulley. Dr. Czakó received her Ph.D. degree (2006) in synthetic organic chemistry under the guidance of Professor Gary A. Molander at the University of Pennsylvania. Currently she is a postdoctoral fellow with Professor E.J. Corey at Harvard University. In 2005 she published with László Kürti the textbook Strategic Applications of Named Reactions in Organic Synthesis.

László Kürti was born and raised in Hungary. He received his diploma from the University of Debrecen, Hungary, where he conducted research in the laboratory of Professor Sándor Antus. Subsequently he received his Master of Science degree at the University of Missouri-Columbia working with Professor Michael Harmata, and his Ph.D. degree (2006) in synthetic organic chemistry under the supervision of Professor Amos B. Smith III (the University of Pennsylvania). Currently he is a Damon Runyon Cancer Fellow in the group of Professor E.J. Corey at Harvard University. In 2005 he published with Barbara Czakó the textbook Strategic Applications of Named Reactions in Organic Synthesis.

"Dieses Werk schließt eine Lücke in der didaktischen Literatur und wird in der Ausbildung von Wissenschaftlern enorm von Nutzen sein."Angewandte Chemie, 2008, 120, 2203-2205

Molecules and Medicine is a fascinating introduction to the convergence of chemistry and physiology, and to the emergence of the science of molecular medicine. ( The Nucleus , January 2010) " Molecules and Medicine is extremely well organized and integrates history, chemistry, biology, and pharmacology of drug development seamlessly." ( The Quarterly Review of Biology , September 2008) " I find this to be a useful book for somemone teaching a biochemistry class. Use of examples and information from Molecules and Medicine should make material in lectures seem more relevant to students and assist motivation for learning." ( Biochemistry and Molecular Biology Education , May/June 2008) "This is a treasure trove of information about molecules as medicines." ( Education in Chemistry , May 2008) "Molecules and Medicine is an engaging book that takes the reader into the world of small molecule clinical therapeutics and how they are discovered and used to improve health." ( CHOICE , March 2008) " numerous colorful illustrations that help to explain the various topics covered make it easy and interesting reading." ( ChemBioChem , March 2008)