Multiple Testing Procedures with Applications to Genomics
(Sprache: Englisch)
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including...
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Klappentext zu „Multiple Testing Procedures with Applications to Genomics “
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
Inhaltsverzeichnis zu „Multiple Testing Procedures with Applications to Genomics “
- Multiple hypothesis testing- Test statistics null distribution
- Overview of multiple testing procedures
- Single-step multiple testing procedures for controlling general Type 1 error rates
- Augmentation multiple testing procedures for controlling generalized tail probability error rates
- Resampling-based empirical Bayes multiple testing procedures for controlling generalized tail probability error rates
- Simulation studies: Assessment of test statistics null distributions
- Identification of differntially expressed and co-expressed genes in high-throughput gene expression experiments
- Multiple tests of association with biological annotation metadata
- HIV-1 sequence variation and viral replication capacity
- Genetic mapping of complex traits using single nucleotide polymorphisms: The ObeLinks Project
- Software implementation
Bibliographische Angaben
- Autoren: Sandrine Dudoit , Mark J. van der Laan
- 2007, 2008, 590 Seiten, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, New York
- ISBN-10: 0387493166
- ISBN-13: 9780387493169
- Erscheinungsdatum: 19.12.2007
Sprache:
Englisch
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