N-Heterocyclic Carbenes

Preface
 
N-HETEROCYCLIC CERBENES
Introduction
Structure and Properties of NHCs
Abnormal Carbenes
Why Are NHCs Stable?
Bonding of NHCs to Metal Centers
Quantifying the Properties of NHCs
N-Heterocyclic Carbenes in the Context of Other Stable Carbenes
Synthesis of NHCs
Salts and Adducts of NHCs
Summary
 
TUNING AND QUANTIFYING STERIC AND ELECTRONIC EFFECTS OF N-HETEROCYCLIC CARBENES
Introduction
Steric Effects in NHC ligands
Electronic Effects in NHC Ligands
Conclusions
 
CHIRAL MONODENDATE N-HETEROCYCLIC CARBENE LIGANDS IN ASYMMETRIC CATALYSIS
Introduction
NHC-Ru
NHC-Rh
NHC-Ir
NHC-Ni
NHC-Pd
NHC-Cu
NHC-Ag
NHC-Au
Conclusion
 
(N-HETEROCYCLIC CARBENE)-PALLADIUM COMPLEXES IN CATALYSIS
Introduction
Cross-Coupling Reactions
Chelates and Pincer Ligands
Asymmetric Catalysis
Oxidation Reactions
Telomerization, Oligomerization and Polymerization
Anticancer NHC-Pd Complexes
 
NHC PLATINUM(0) COMPLEXES: UNIQUE CATALYSTS FOR THE HYDROSILYLATION OF ALKENES AND ALKYNES
Introduction
Hydrosilylation of Alkenes: The Beginning
Initial Results with Phosphine Ligands
NHC Platinum(0) Complexes: The Breakthrough
Hydrosilylation of Alkynes
Conclusions
 
SYNTHESIS AND MEDICINAL PROPERTIES OF SILVER-NHC COMPLEXES AND IMIDAZOLIUM SALTS
Introduction
Silver-NHC Complexes as Antimicrobial Agents
Silver-NHC Complexes as Anticancer Agents
Conclusions
 
MEDICAL APPLICATIONS OF NHC-GOLD AND -COPPER COMPLEXES
Introduction
Gold Antimicrobial Agents
Metals as Antitumor Reagents
Copper Complexes as Antitumoral Reagents
Conclusion
 
NHC-COPPER COMPLEXES AND THEIR APPLICATIONS
Introduction
History of NHC-Copper Systems
Hydrosilylation
Allene Formation
1,4-Reduction
Conjugate Addition
Hydrothiolation, Hydroalkoxylation, Hydroamination
Carboxylation and Carbonylation (via Boronic Acids, CH Activation): CO2 Insertion
[3 + 2] Cycloaddition

Steven P. Nolan was born in Canada. He received his B.Sc. in Chemistry from the University of West Florida and his Ph.D. from the University of Miami where he worked under the supervision of Professor Carl D. Hoff. After a postdoctoral stay with Professor Tobin J. Marks at Northwestern University, he joined the Department of Chemistry of the University of New Orleans in 1990. In 2006 he joined the Institute of Chemical Research of Catalonia (ICIQ) as Group leader and ICREA Research Professor. In early 2009, he joined the School of Chemistry at the University of St Andrews where he is Professor and holds the Chair in Inorganic chemistry.