Nano-Oncologicals
Targeting and Delivery Approaches
(Sprache: Englisch)
This authoritative volume focuses on emerging technologies in cancer nano medicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of...
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This authoritative volume focuses on emerging technologies in cancer nano medicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nano theranostics and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines).Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nano carriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through
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clinical development.
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Inhaltsverzeichnis zu „Nano-Oncologicals “
1: Biological barriers in cancer therapy- Alberto Gabizon, The Hebrew University of Jerusalem, Jerusalem, Israel
- Kinam Park, Purdue University, West Lafayette, IN, US
2: Passive vs active targeting, an update of the EPR role
- Jean C. Leroux, EHT, Zurich, Switzerland
3: Biomarkers and targeting ligands in cancer nanotherapy
- Jessie L.-S. Au, the Ohio State University, US
- Louis M. Weiner, Georgetown University Medical Center, Washington DC, US
4: Metal Organic Frameworks for theranostics
- Patrick Couvreur, University of Paris Sud, France
5: Micro- bubbles and theranostics
- Joyce Wong, Boston University, USA
6: Iron oxide nanoparticles for theranostics
- Twan Lammers, University of Twente, Enschede (NL)
- Yuri Volkov, Trinity College Dublin, Dublin (IRL)
7: Multilayer assemblies as carriers for oncologicals
- Paula Hammond, MIT, Cambridge, MA, US
- Erkki Ruoslahti, Wayne State University, Detroit, MI, US.
- Weiyue Lu, School of Pharmacy, Fudan University, Shanghai, China
- Yong Zhang, National University of Singapore, Singapore
8: Phototargeted nanoparticles as carriers for oncologicals
- Daniel Kohane, Children hospital, Boston, MA, US
9: Targeted liposomes and micelles as carriers for oncologicals
- Vladimir Torchilin, Western University, Boston, MA, US
- Kazunory Kataoka, The University of Tokyo, Tokyo, Japan
10: Cancer immunomodulation and immunosupressing cells
- Enzo Bronte; Istituto Oncologico Veneto (IOV), IRCCS, 35128 Padua, Italy
- Alberto Mantovani, University of Milan, Rozzano, Italy
- Lisa M. Coussens, University of California, San Francisco, CA, US
11: Polymer-base delivery vehicles for anticancer vaccines
- Jeffrey Hubell, EPFL, Lausane, Switzerland
- David Mooney, Harvard University, Boston, US
12: Liposomes and immunomodulation
- Gert Storm, Utrecht University, Utrecht, The Netherlands
- G. Lopez-Berenstein, MD Anderson, Houston, TX, US
- Afsaneh Lavasanifar, University of
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Alberta, Edmonton, Alberta, Canada
13: Novel polymers for RNA delivery
- Mark Davis, Caltech, Pasadena, CA, US
- Ernest Wagner, Ludwig-Maximilians-Universität, Munich, Germany
- Mansoor Amiji, Northeastern University, Boston, MA, US
14: Lipids and lipoids for RNA delivery
- L Huang, University of North Carolina, Chapel Hill, NC, US
- Dan Anderson, MIT, Cambridge, MA, US
15: Toxicity and regulatory aspects of oncologicals
- Ruth Duncan, University of Cardiff, UK
- Rogerio Gaspar, University of Lisbon, Portugal
- Bengt Fadeel, Karolinska Institute, Sweden
16: Case study: PLA-PEG targeted nanoparticles
- Jeff Hrkach, Bind Biosciences, Boston, US
17: Case study: gene therapy using polymer carriers
- Marisol Soengas, Bioncotherapies, Valencia, Spain?
13: Novel polymers for RNA delivery
- Mark Davis, Caltech, Pasadena, CA, US
- Ernest Wagner, Ludwig-Maximilians-Universität, Munich, Germany
- Mansoor Amiji, Northeastern University, Boston, MA, US
14: Lipids and lipoids for RNA delivery
- L Huang, University of North Carolina, Chapel Hill, NC, US
- Dan Anderson, MIT, Cambridge, MA, US
15: Toxicity and regulatory aspects of oncologicals
- Ruth Duncan, University of Cardiff, UK
- Rogerio Gaspar, University of Lisbon, Portugal
- Bengt Fadeel, Karolinska Institute, Sweden
16: Case study: PLA-PEG targeted nanoparticles
- Jeff Hrkach, Bind Biosciences, Boston, US
17: Case study: gene therapy using polymer carriers
- Marisol Soengas, Bioncotherapies, Valencia, Spain?
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Autoren-Porträt
Prof. Maria José Alonso University of Santiago de Compostela (USC), Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS) Avda Barcelona, Spain Dr. Marcos Garcia-Fuentes University of Santiago de Compostela (USC), Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS) Avda Barcelona, Spain.
Bibliographische Angaben
- 2014, 2014, XIV, 473 Seiten, 51 farbige Abbildungen, Maße: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Maria José Alonso, Marcos Garcia-Fuentes
- Verlag: Springer, Berlin
- ISBN-10: 3319080830
- ISBN-13: 9783319080833
Sprache:
Englisch
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