Natural Lactones and Lactams

PrefaceTETRONIC ACIDSIntroductionNatural Occurrence, Biological Activities, and Biosynthesis5-Ylidene Tetronic Natural Products5-Monosubstituted Tetronic Natural Products5-Disubstituted Tetronic Natural Products5-Unsubstituted Tetronic Natural ProductsConclusionsRECENT ADVANCES IN THE FIELD OF NATURALLY OCCURRING 5,6-DIHYDROPYRAN-2-ONESIntroductionSynthetic Methodologies for 5,6-Dihydropyran-2-onesFormation of Stereogenic Centers inside the Dihydropyrone RingPharmacological Properties of PyronesBiosynthetic Formation of PyronesSyntheses of Natural 5,6-Dihydropyran-2-ones Reported during the Period from 2006 to the First Half of 2012BETA-LACTAMSIntroductionMonocyclic Beta-LactamsPenamsCephalosporinsClavulanic AcidCarbapenemsSpiro-Fused Beta-LactamsSummaryALPHA-ALKYLIDENE-GAMMA- AND DELTA-LACTONES AND LACTAMSIntroductionOccurrence, Biosynthesis, and Biological Activities of Alpha-Alkylidene Gamma- and Delta-Lactones and LactamsRecent Advances in the Synthesis of Alpha-Alkylidene Gamma- and Delta-Lactones and LactamsConclusionsMEDIUM-SIZED LACTONESIntroductionTotal Synthesis of Eight-Membered LactonesTotal Synthesis of Nine-Membered LactonesConclusionsMACROLACTONESIntroductionGeneral Methods for the Synthesis of MacrolactonesSynthesis of MacrolidesSynthesis of MacrodiolidesSynthesis of MacrotriolidesConclusions and PerspectivesRESORCYLIC ACID LACTONESIntroduction - A Historical PerspectiveBiosynthesisChemical SynthesisConclusion and OutlookCYCLIC PEPTIDESIntroductionSynthesis of Natural Lactones and LactamsConclusionIndex

Tomasz Janecki was born in Lodz (Poland) and studied chemistry at the Lodz University of Technology. He obtained his doctorate in 1981 under the guidance of Ryszard Bodalski. After postdoctoral appointments at Strathclyde University (Peter Pauson) and the University of Texas at Austin (Josef Michl and Karl Folkers), he began an independent research career and completed his "Habilitation" at the Lodz University of Technology in 1996. Currently, he is a Full Professor of Organic Chemistry at the same university. His main research interest is the application of organophosphorus reagents in stereoselective synthesis of biologically important classes of organic compounds.