Natural Products in Medicinal Chemistry

Preface
 
PART ONE: Natural Products as Sources of Potential Drugs and Systematic Compound Collections
 
NATURAL PRODUCTS AS DRUGS AND LEADS: AN INTRODUCTION AND PERSPECTIVE AS OF THE END OF 2012
Introduction
The Sponge-Derived Nucleoside Link to Drugs
Initial Recognition of Microbial Secondary Metabolites as Antibacterial Drugs
Beta-Lactams of All Classes
Tetracycline Derivatives
Glycopeptide Antibacterials
Lipopeptide Antibacterials
Macrolide Antibiotics
Pleuromutilin Derivatives
Privileged Structures
The Origin of the Benzodiazepines
Benzopyrans: A Source of Unusual Antibacterial and Other Agents
Multiple Enzymatic Inhibitors from Relatively Simple Natural Product Secondary Metabolites
A Variation on BIOS: The "Inside-Out" Approach
Other Privileged Structures
Privileged Structures and Inhibitors of Protein-Protein Interactions
Underprivileged Scaffolds
So Where Should One Look in the Twenty-First Century for Novel Structures from Natural Sources?
Conclusions
 
NATURAL PRODUCT-DERIVED AND NATURAL PRODUCT-INSPIRED COMPOUND COLLECTIONS
Introduction
Modern Approaches to Produce Natural Product Libraries
Prefractionated Natural Product Libraries
Libraries of Pure Natural Products
Semisynthetic Libraries of Natural Product-Derived Compounds
Synthetic LIbraries of Natural Product-Inspired Compounds
Compound Collections with Carbocyclic Core Structures
Compound Cllections iwth Oxa-Heterocyclic Scaffolds
Compound Collections with Aza-Heterocyclic Scaffolds
Macrocyclic Compound Collections
Outlook
 
PART TWO: From Marketed Drugs to Designed Analogs and Clinical Candidates
 
CHEMISTRY AND BIOLOGY OF EPOTHILONES
Introduction: Discovery and Biological Activity
Synthesis of Natural Epothilones
Synthesis and Biological Activity of Nonnatural Epothilones
Conformational Studies and Pharmacophore Modeling
Conclusions
 
TAXOL, TAXOIDS, AND RELATED TAXANES
Introduction and Historical Background
Mechanism

Stephen Hanessian holds the Isis Pharmaceuticals Research Chair at the University of Montreal and is also on the faculty of the Departments of Chemistry, Pharmaceutical Sciences and Pharmacology at the University of California, Irvine. He has received numerous awards and distinctions, the latest being the 2012 Ernest Guenther Award in the Chemistry of Natural Products from the American Chemical Society, the IUPAC-Richter Prize in Medicinal Chemistry, and the Montreal InVivo Prize for innovation. Professor Hanessian has over 500 journal publications to his name, which span a wide cross-section of areas related to organic, bioorganic, and medicinal chemistry. His latest book "Design and Strategy in Organic Synthesis - From the Chiron Approach to Catalysis" (Wiley-VCH) has received wide acclaim.

"Generally, it is a well-presented book and can be used as a useful reference by natural products researchers." ( ChemMedChem , 1 November 2014)