Novel Antimicrobial Agents and Strategies

PrefaceTHE PROBLEM OF MICROBIAL DRUG RESISTANCEIntroductionHistory of the Origins, Development, and Use of Conventional AntibioticsProblems of Antibiotic ResistanceMultiple Drug-Resistant (MDR), Extensively Drug-Resistant (XFR), and Pan-Drug-Resistant (PDR) OrganismsMDR Mechanisms of Major PathogensAntimicrobial Stewardship ProgramsDiscussionCONVENTIONAL ANTIBIOTICS - REVITALIZED BY NEW AGENTSIntroductionConventional AntibioticsThe Principle of Combination Antibiotic TherapyAntibiotic Resistance Breakers: Revitalize Conventional AntibioticsDiscussionDEVELOPING NOVEL BACTERIAL TARGETS: CARBONIC ANHYDRASES AS ANTIBACTERIAL DRUG TARGETSIntroductionCarbonic AnhydrasesCA InhibitorsClasses of CAs Present in BacteriaPathogenic Bacterial CAsAlpha-CAs in Pathogenic BacteriaBeta-CAs in Pathogenic BacteriaGamma-CAs from Pathogenic BacteriaConclusionsMAGAININS - A MODEL FOR DEVELOPMENT OF EUKARYOTIC ANTIMICROBIAL PEPTIDES (AMPs)IntroductionMagainins and Their Antimicrobial ActionMagainins as AntibioticsOther Antimicrobial Uses of MagaininsFuture Prospects for MagaininsANTIMICROBIAL PEPTIDES FROM PROKARYOTESIntroductionBacteriocinsApplications of Prokaryotic AMPsDevelopment and Discovery of Novel AMPPEPTIDOMIMETICS AS ANTIMICROBIAL AGENTSIntroductionAntimicrobial PeptidomimeticsDiscussionSYNTHETIC BIOLOGY AND THERAPIES FOR INFECTIOUS DISEASESCurrent Challenges in the Treatment of Infectious DiseasesIntroduction to Synthetic BiologyVaccinologyBacteriophages: A Re-emerging Solution?Isolated Phage Parts as AntimicrobialsPredatory Bacteria and Probiotic Bacterial TherapyNatural Products Discovery and EngineeringSummaryNANO-ANTIMICROBIALS BASED ON METALSIntroductionSilver Nano-AntimicrobialsCopper Nano-AntimicrobialsZinc Oxide Nano-AntimicrobialsConclusionsNATURAL PRODUCTS AS ANTIMICROBIAL AGENTS - AN UPDATEIntroductionAntimicrobial Natural Products from PlantsAntimicrobial Natural Products Bearing an Acetylene FunctionAntimicrobial CarbohydratesAntimicrobial Natural

Professor David Andrew Phoenix, OBE, DUniv, AcSS, DSc studied Biochemistry and was later awarded a Doctor of Science by Liverpool University for his impact on the field. He has over 200 publications and has held chairs in the UK, Canada, China and Russia. He is a Fellow of the Royal Society of Chemistry, the Society of Biology, the Institute of Mathematics and its Applications and the Royal Society of Medicine. He was elected to Fellowship of the Royal College of Physicians (Edinburgh) for his contribution to medical research and education, made an Officer of the Most Excellent Order of the British Empire for servcies to Science and Higher Education and recognized as an Academician by the Academy of Social Sciences. He is currently the Vice Chancellor of London South Bank University.Dr. Frederick Harris PhD studied at UCLan, graduating with a Bachelor of Science in Biochemistry and Microbiology in 1993 before gaining his Doctorate for work on the penicillin-binding proteins of Escherichia coli in 1998. Subsequently, he has undertaken research at Utrecht University and the Leibniz-Centre for Medicine and Biosciences, Germany. In 2000, Frederick started as a Research Fellow at UCLan and now has more than 75 publications to his name, which primarily focus on antimicrobial and anticancer peptides.Dr. Sarah Rachel Dennison PhD graduated from the University of Wales, Bangor with a Bachelor of Science in Environmental Biology in 1999. Subsequently, she undertook postgraduate research in Biochemistry / Biophysics, which led to a doctorate in 2004. Currently, Sarah is a Research Associate at UCLan where she is investigating the role of amphiphilicity in the function of antimicrobial peptides using a number of biophysical techniques such as Langmuir Blodgettry and antimicrobial assays. She has produced over 50 publications from her research and parallel collaborative work.