Patient-Specific Modeling of the Cardiovascular System
Technology-Driven Personalized Medicine
(Sprache: Englisch)
The main purpose of the book is to demonstrate the design of a variety of patient-specific models within the cardiovascular system in computational biology. The maturation of computational biology could lead to a new approach to medicine. During the last...
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The main purpose of the book is to demonstrate the design of a variety of patient-specific models within the cardiovascular system in computational biology. The maturation of computational biology could lead to a new approach to medicine. During the last five to ten years, there have been many improvements in diagnostic medical technologies such as multi-slice cardiac CT imaging, 3-D electroanatomic mapping, and many types of applications of Magnetic Resonance Imaging (i.e. magnetic resonance tagging and diffusion tensor imaging). Combined with more powerful computing resources and more accurate predictive computational models it is feasible to begin developing mechanistic patient-specific models that may help diagnosis, guide therapy or surgery, and predict outcomes of the latter. Many questions need to be answered before computational modeling can be fully integrated with standard care, such as what is the minimal data set needed from the patient in order to build a reliable predictive model? What accuracy is needed? How will the initial baseline model be validated? What are reasonable computation times? Is some type of perturbation of the patient's physiology necessary? How could they be integrated with current practices? Are physicians willing to accept these models? These questions will also serve as guidelines throughout the chapters. The book will try to cover, such as cardiac electrophysiology, cardiac (muscle) mechanics, circulation dynamics, arterial and venous flow, angiogenesis, remodeling, metabolism, or combinations between these such as cardiac electromechanics or fluid-solid interactions.
Klappentext zu „Patient-Specific Modeling of the Cardiovascular System “
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.
Inhaltsverzeichnis zu „Patient-Specific Modeling of the Cardiovascular System “
Foreward.- Preface.- Integrating State-of-the-Art Computational Modeling with Clinical Practice: The Promise of Numerical Methods.- Patient-specific Modeling of Cardiovascular Dynamics with a Major Role for Adaptation.- Patient-specific Modeling of Structure and Function of Cardiac Cells.- Studies of Therapeutic Strategies for Atrial Fibrillation based on a Biophysical Model of the Human Atria.- Patient-specific Modeling for Critical Care.- Biomechanical Analysis of Abdominal Aortic Aneurysms.- The Cardiac Atlas Project: Towards a Map of the Heart.- In Vivo Myocardial Material Properties and Stress Distributions in Normal and Failing Human Hearts.- Modeling of Whole-Heart Electrophysiology and Mechanics: Towards Patient-specific Simulations.- Personalized Computational Models of the Heart for Cardiac Resynchronization Therapy.- Patient-specific Modeling of Hypoxic Response and Microvascular Dynamics.- A Computational Framework for Patient-specific Multi-scale Cardiac Modeling.- Appendix.- Index.
Bibliographische Angaben
- 2010, XXI, 240 Seiten, Maße: 16,2 x 24,5 cm, Gebunden, Englisch
- Herausgegeben: Roy C.P. Kerckhoffs
- Verlag: Springer, Berlin
- ISBN-10: 1441966900
- ISBN-13: 9781441966902
Sprache:
Englisch
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