PET for Drug Development and Evaluation

one: Introduction.- 1. Drug development and positron emission tomography.- 2. Positron emission tomography: Basic principles and potential interest for pharmacological studies.- 3. Is PET a tool for drug evaluation?.- two: Psychiatry.- 4. PET in neuropsychiatric drug development.- 5. Radioligand disposition and metabolism - Key information in early drug development.- 6. PET studies in the early clinical development of a new antipsychotic.- 7. PET in the development of Dopamine D1 antagonists as new potential antipsychotic drugs.- 8. Is the 5-HT2-receptor a target for antipsychotic drug action? PET studies on dopamine (D2) and serotonin (5-HT2) receptor occupancy in patients and healthy subjects.- 9. Preclinical development of a radioligand for the study of central 5-HT1A receptors with PET-[11C]WAY-100635.- 10. Comparative in vivo and in vitro selectivity of zolpidem for ? (Benzodiazepine) modulatory site subtypes.- 11. Do the effects of muscarinic receptor blockade on brain glucose consumption mimic the cortical and subcortical metabolic pattern of Alzheimer's disease in normal volunteers?.- three: Neurology.- 12. PET evaluation of drug treatment in ischemic stroke and Alzheimer's disease.- 13. PET imaging of cerebral perfusion and oxygen metabolism in acute ischemic stroke: Implications for management and therapy.- 14. Pharmacokinetics: Kinetic modelling of MAO inhibitors and D2 antagonists.- 15. Brain activation under drug treatment.- 16. Modifying the progression of Parkinson's disease.- 17. COMT inhibition: Pharmacology of tolcapone and 6-[18F]-Fluoro-L-Dopa (FDOPA) PET results.- 18. Interaction of Lisuride with dopaminergic receptors.- 19. Lisuride and [C-ll]-raclopride interaction at the D2 receptor site.- four: Cardiology.- 20. Drug design in cardiology:The pharmaceutical industry point of view.- 21. Myocardial receptors and their interaction with cardiovascular drugs.- 22. The pathophysiological background of cardiovascular diseases and its impact on