Pharmaceutical Biotechnology
Concepts and Applications
(Sprache: Englisch)
Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast moving area of biopharmaceuticals.
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Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast moving area of biopharmaceuticals.
Klappentext zu „Pharmaceutical Biotechnology “
Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products.* introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science
* an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students
* includes specific 'product category chapters' focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products
* entire chapter devoted to the principles of genetic engineering and how these drugs are developed
* includes numerous relevant case studies to enhance student understanding
* no prior knowledge of protein structure is assumed
Inhaltsverzeichnis zu „Pharmaceutical Biotechnology “
PrefaceAcronyms
1 Pharmaceuticals, biologics and biopharmaceuticals
1.1 Introduction to pharmaceutical products
1.2 Biopharmaceuticals and pharmaceutical biotechnology
1.3 History of the pharmaceutical industry
1.4 The age of biopharmaceuticals
1.5 Biopharmaceuticals: current status and future prospects
2 Protein structure
2.1 Introduction
2.2 Overview of protein structure
2.3 Higher level structure
2.4 Protein stability and folding
2.5 Protein post-translational modifi cation
3 Gene manipulation and recombinant DNA technology
3.1 Introduction
3.2 Nucleic acids: function and structure
3.3 Recombinant production of therapeutic proteins
3.4 Classical gene cloning and identifi cation
4 The drug development process
4.1 Introduction
4.2 Discovery of biopharmaceuticals
4.3 The impact of genomics and related technologies upon drug discovery
4.4 Gene chips
4.5 Proteomics
4.6 Structural genomics
4.7 Pharmacogenetics
4.8 Initial product characterization
4.9 Patenting
4.10 Delivery of biopharmaceuticals
4.10.3 Nasal, transmucosal and transdermal delivery systems
4.11 Preclinical studies
4.12 Pharmacokinetics and pharmacodynamics
4.13 Toxicity studies
4.14 The role and remit of regulatory authorities
4.15 Conclusion
5 Sources and upstream processing
5.1 Introduction
5.2 Sources of biopharmaceuticals
5.3 Upstream processing
6 Downstream processing
6.1 Introduction
6.2 Initial product recovery
6.3 Cell disruption
6.4 Removal of nucleic acid
6.5 Initial product concentration
6.6 Chromatographic purifi cation
6.7 High-performance liquid chromatography of proteins
6.8 Purifi cation of recombinant proteins
6.9 Final product formulation
7 Product analysis
7.1 Introduction
7.2 Protein-based contaminants
7.3 Removal of altered forms of the protein of interest from the product stream
7.4 Detection of protein-based product
... mehr
impurities
7.5 Immunological approaches to detection of contaminants
7.6 Endotoxin and other pyrogenic contaminants
8 The cytokines: The interferon family
8.1 Cytokines
8.1.1 Cytokine receptors
8.1.2 Cytokines as biopharmaceuticals
8.2 The interferons
8.3 Interferon biotechnology
8.4 Conclusion
9 Cytokines: Interleukins and tumour necrosis factor
9.1 Introduction
9.2 Interleukin-2
9.3 Interleukin-1
9.4 Interleukin-11
9.5 Tumour necrosis factors
10 Growth factors
10.1 Introduction
10.2 Haematopoietic growth factors
10.3 Growth factors and wound healing
11 Therapeutic hormones
11.1 Introduction
11.2 Insulin
11.3 Glucagon
11.4 Human growth hormone
11.5 The gonadotrophins
11.6 Medical and veterinary applications of gonadotrophins
11.7 Additional recombinant hormones now approved
11.8 Conclusion
12 Recombinant blood products and therapeutic enzymes
12.1 Introduction
12.2 Haemostasis
12.3 Anticoagulants
12.4 Thrombolytic agents
12.5 Enzymes of therapeutic value
13 Antibodies, vaccines and adjuvants
13.1 Introduction
13.2 Traditional polyclonal antibody preparations
13.3 Monoclonal antibodies
13.4 Vaccine technology
13.5 Adjuvant technology
14 Nucleic-acid- and cell-based therapeutics
14.1 Introduction
14.2 Gene therapy
14.3 Vectors used in gene therapy
14.4 Gene therapy and genetic disease
14.5 Gene therapy and cancer
14.6 Gene therapy and AIDS
14.7 Antisense technology
14.8 Oligonucleotide pharmacokinetics and delivery
14.9 Aptamers
14.10 Cell- and tissue-based therapies
14.11 Conclusion
Index
7.5 Immunological approaches to detection of contaminants
7.6 Endotoxin and other pyrogenic contaminants
8 The cytokines: The interferon family
8.1 Cytokines
8.1.1 Cytokine receptors
8.1.2 Cytokines as biopharmaceuticals
8.2 The interferons
8.3 Interferon biotechnology
8.4 Conclusion
9 Cytokines: Interleukins and tumour necrosis factor
9.1 Introduction
9.2 Interleukin-2
9.3 Interleukin-1
9.4 Interleukin-11
9.5 Tumour necrosis factors
10 Growth factors
10.1 Introduction
10.2 Haematopoietic growth factors
10.3 Growth factors and wound healing
11 Therapeutic hormones
11.1 Introduction
11.2 Insulin
11.3 Glucagon
11.4 Human growth hormone
11.5 The gonadotrophins
11.6 Medical and veterinary applications of gonadotrophins
11.7 Additional recombinant hormones now approved
11.8 Conclusion
12 Recombinant blood products and therapeutic enzymes
12.1 Introduction
12.2 Haemostasis
12.3 Anticoagulants
12.4 Thrombolytic agents
12.5 Enzymes of therapeutic value
13 Antibodies, vaccines and adjuvants
13.1 Introduction
13.2 Traditional polyclonal antibody preparations
13.3 Monoclonal antibodies
13.4 Vaccine technology
13.5 Adjuvant technology
14 Nucleic-acid- and cell-based therapeutics
14.1 Introduction
14.2 Gene therapy
14.3 Vectors used in gene therapy
14.4 Gene therapy and genetic disease
14.5 Gene therapy and cancer
14.6 Gene therapy and AIDS
14.7 Antisense technology
14.8 Oligonucleotide pharmacokinetics and delivery
14.9 Aptamers
14.10 Cell- and tissue-based therapies
14.11 Conclusion
Index
... weniger
Autoren-Porträt von Gary Walsh
Dr Gary Walsh. Chemical and Environmental Science Department, University of Limerick, Limerick, Republic of Ireland, Gary.Walsh@il.ie
Bibliographische Angaben
- Autor: Gary Walsh
- 2007, 1. Auflage, 528 Seiten, Maße: 25,4 cm, Gebunden, Englisch
- Verlag: Wiley & Sons
- ISBN-10: 0470012447
- ISBN-13: 9780470012444
Sprache:
Englisch
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