Photosensitisers in Biomedicine
(Sprache: Englisch)
Photosensitisers in Biomedicine offers clear and comprehensive coverage of the many different photosensitiser types, including information on their many applications that now extend beyond anticancer therapy. These applications now include...
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Photosensitisers in Biomedicine offers clear and comprehensive coverage of the many different photosensitiser types, including information on their many applications that now extend beyond anticancer therapy. These applications now include photoantimicrobial treatments not only in microbial disease, but also in the microbial resistance to conventional drugs, which is circumvented by photomicrobial action. The application of photoantimicrobials in biological fluids is also of considerable importance in the current era of HIV and is discussed in the book.This text offers the most up-to-date coverage of photodynamic therapy including information on how photosensitisers have evolved within the field of cancer therapy and more recently antimicrobial research. There are few books on the market that take the approach of this text, as many are either conference based or focus on the chemistry of photosensitisers.Photosensitisers in Biomedicine is clearly defined into three distinct partsbeginning with a clear introduction to the various types of photosensitisers. The book then moves on to discuss the chemistry of photosensitisers and closes with their numerous applications, for example, photodynamic therapy, photodiagnosis, photodynamic antimicrobial chemotherapy (PACT) and other non-oncological applications such as optical, arterial plaques and stents.
Photosensitisers in Biomedicine offers clear and comprehensive coverage of the many different photosensitiser types, including information on their many applications that now extend beyond anticancer therapy. These applications now include photoantimicrobial treatments not only in microbial disease, but also in the microbial resistance to conventional drugs, which is circumvented by photomicrobial action. The application of photoantimicrobials in biological fluids is also of considerable importance in the current era of HIV and is discussed in the book.
This text offers the most up-to-date coverage of photodynamic therapy including information on how photosensitisers have evolved within the field of cancer therapy and more recently antimicrobial research. There are few books on the market that take the approach of this text, as many are either conference based or focus on the chemistry of photosensitisers.
Photosensitisers in Biomedicine is clearly defined into three distinct parts beginning with a clear introduction to the various types of photosensitisers. The book then moves on to discuss the chemistry of photosensitisers and closes with their numerous applications, for example, photodynamic therapy, photodiagnosis, photodynamic antimicrobial chemotherapy (PACT) and other non-oncological applications such as optical, arterial plaques and stents.
This text offers the most up-to-date coverage of photodynamic therapy including information on how photosensitisers have evolved within the field of cancer therapy and more recently antimicrobial research. There are few books on the market that take the approach of this text, as many are either conference based or focus on the chemistry of photosensitisers.
Photosensitisers in Biomedicine is clearly defined into three distinct parts beginning with a clear introduction to the various types of photosensitisers. The book then moves on to discuss the chemistry of photosensitisers and closes with their numerous applications, for example, photodynamic therapy, photodiagnosis, photodynamic antimicrobial chemotherapy (PACT) and other non-oncological applications such as optical, arterial plaques and stents.
Inhaltsverzeichnis zu „Photosensitisers in Biomedicine “
Author's introductionPART 1: INTRODUCTION
1. Light
1.1 Electromagnetic radiation in everyday life
1.2 Radiation and tissue
1.3 Light, electrons and molecules
1.4 Photoreaction
1.5 Dental/plastics curing
1.6 Photoaging/photofading/photobleaching
References
2. Dyes and stains
2.1 Dye use
2.2 Textile dyeing and biological staining
2.3 Biological stains and biomedical photosensitisers
2.4 The human factor
2.5 Dyes and drug development
2.6 Dyes and stains and photosensitiser design
References
3. Photosensitisers and photosensitisation
3.1 Photosensitiser action
3.2 The photodynamic effect and cell death
3.3 Photosensitising drug discovery
3.4 Fitness for purpose
3.5 Organic versus inorganic photosensitisers
References
PART 2: CHEMISTRY OF PHOTOSENSITISERS
4. Azines
4.1 Acridines
4.2 Acridine synthesis
4.3 Rationale
4.4 Acridines in photodynamic therapy
4.5 Phenanthridines
4.6 Phenaziniums
4.7 Phenoxaziniums
4.8 Phenothiazinium derivatives
4.9 Reduction--oxidation activity
4.10 Hydrophilicity?lipophilicity
4.11 Molecular planarity
4.12 Benzannelated derivatives
4.13 Synthetic approaches
References
5. Triarylmethanes and xanthenes
5.1 Triarylmethanes
5.2 Victoria blue series
5.3 Structure and photoproperties in triarylmethanes -- extending the long-wavelength absorption
5.4 Synthesis
5.5 Xanthene derivatives
5.6 Biological uses
5.7 Rhodamines
5.8 Rosamines
5.9 Pyrylium compounds
5.10 Pyronines
References
6. Porphyrins
6.1 Central metals
6.2 Meso compounds
6.3 Amino derivatives
6.4 Hetero-porphyrins
6.5 Chlorins
6.6 Benzoporphyrin derivative
6.7 Temoporfin
6.8 Tookad
6.9 Purpurins
6.10 Texaphyrins
6.11 Porphycenes
6.12 5-Aminolaevulinic acid
6.13 Esters
References
7. Phthalocyanines
7.1 General features
7.2 Phthalocyanine synthesis
7.3 Photosens
7.4 Naphthalocyanines
7.5 Hetero-fused systems
7.6 Silicon derivatives
7.7 Photoantimicrobial activity
References
8. Cyanines
8.1 Synthesis
8.2
... mehr
Merocyanine 540
8.3 N,N'-bis(2-ethyl-l,3-dioxolane)kryptocyanine
8.4 Indocyanine green
8.5 Structural improvement
8.6 Squaric and croconic acid derivatives
8.7 Functional cyanines
References
9. Natural product photosensitisers
9.1 Condensed aromatic pigments: perylene- and phenanthroperylenequinones
9.2 Hypericin-type photosensitisers
9.3 Hypocrellins
9.4 Anthraquinones
9.5 Psoralens (furocoumarins)
9.6 Isoquinoline alkaloid photosensitisers
9.7 Riboflavin
9.8 Terthiophenes
References
PART 3: APPLICATIONS
10. PDT in oncology
10.1 Photosensitisers for use in photodynamic therapy
10.2 Indications for photodynamic therapy
10.3 Skin
10.4 Head and neck
10.5 Gastrointestinal tract
10.6 Breast
10.7 Lung
10.8 Genitourinary tract and prostate
10.9 Brain
10.10 Haematological disease (leukaemia and lymphoma)
10.11 Targeting/formulation
10.12 Liposomes
10.13 Biomolecular conjugation
10.14 Dendrimers
10.15 Nanoparticles
10.16 Magnetic targeting
10.17 Light in photodynamic therapy
References
11. Antimicrobial -- PACT
11.1 Antimicrobial and photoantimicrobial action
11.2 Applications
11.3 Blood
11.4 Thionin/light + low-dose UVB for the decontamination of platelet concentrates
11.5 The cellular problem
11.6 A role for photodynamic antimicrobial chemotherapy in tropical medicine
References
12. Non-oncological applications
12.1 Age-related macular degeneration
12.2 Atherosclerosis
12.3 Endometreosis
12.4 Port wine stain
12.5 Arthritis and autoimmune disorders
12.6 Photodynamic diagnosis
12.7 Photocytotoxics and photochemical internalisation
References
Index
8.3 N,N'-bis(2-ethyl-l,3-dioxolane)kryptocyanine
8.4 Indocyanine green
8.5 Structural improvement
8.6 Squaric and croconic acid derivatives
8.7 Functional cyanines
References
9. Natural product photosensitisers
9.1 Condensed aromatic pigments: perylene- and phenanthroperylenequinones
9.2 Hypericin-type photosensitisers
9.3 Hypocrellins
9.4 Anthraquinones
9.5 Psoralens (furocoumarins)
9.6 Isoquinoline alkaloid photosensitisers
9.7 Riboflavin
9.8 Terthiophenes
References
PART 3: APPLICATIONS
10. PDT in oncology
10.1 Photosensitisers for use in photodynamic therapy
10.2 Indications for photodynamic therapy
10.3 Skin
10.4 Head and neck
10.5 Gastrointestinal tract
10.6 Breast
10.7 Lung
10.8 Genitourinary tract and prostate
10.9 Brain
10.10 Haematological disease (leukaemia and lymphoma)
10.11 Targeting/formulation
10.12 Liposomes
10.13 Biomolecular conjugation
10.14 Dendrimers
10.15 Nanoparticles
10.16 Magnetic targeting
10.17 Light in photodynamic therapy
References
11. Antimicrobial -- PACT
11.1 Antimicrobial and photoantimicrobial action
11.2 Applications
11.3 Blood
11.4 Thionin/light + low-dose UVB for the decontamination of platelet concentrates
11.5 The cellular problem
11.6 A role for photodynamic antimicrobial chemotherapy in tropical medicine
References
12. Non-oncological applications
12.1 Age-related macular degeneration
12.2 Atherosclerosis
12.3 Endometreosis
12.4 Port wine stain
12.5 Arthritis and autoimmune disorders
12.6 Photodynamic diagnosis
12.7 Photocytotoxics and photochemical internalisation
References
Index
... weniger
Bibliographische Angaben
- Autor: Mark Wainwright
- 2009, 1. Auflage., 352 Seiten, Maße: 24,4 cm, Gebunden, Englisch
- Verlag: Wiley & Sons
- ISBN-10: 0470510609
- ISBN-13: 9780470510605
Sprache:
Englisch
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