Principles of Behavioral Genetics
(Sprache: Englisch)
How do genes determine behavior? How much of behavior is nature versus nurture? How do behaviors evolve? Anholt and Mackay, leading scholars in the field of behavioral genetics, address these questions and much more in this comprehensive textbook that...
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How do genes determine behavior? How much of behavior is nature versus nurture? How do behaviors evolve? Anholt and Mackay, leading scholars in the field of behavioral genetics, address these questions and much more in this comprehensive textbook that defines the emerging field of behavioral genetics. The text provides a range of examples, such as laboratory studies on flies and mice, field observations on species as diverse as butterflies and meerkats, and human behavioral disorders. The book blends classical and modern genetic principles with neurobiological and ecological perspectives to teach students how to find and map genes that affect behaviors, as well as how the coordinated expression of ensembles of these genes enables the nervous system to express complex behaviors in response to changes in the environment. Principles of Behavioral Genetics introduces us to the fascinating science that aims to understand how our genes determine what makes us tick.
Klappentext zu „Principles of Behavioral Genetics “
Principles of Behavioral Genetics provides an introduction to the fascinating science that aims to understand how our genes determine what makes us tick. It presents a comprehensive overview of the relationship between genes, brain, and behavior. Introductory chapters give clear explanations of basic processes of the nervous system and fundamental principles of genetics of complex traits without excessive statistical jargon. Individual chapters describe the genetics of social interactions, olfaction and taste, memory and learning, circadian behavior, locomotion, sleep, and addiction, as well as the evolution of behavior.
Whereas the focus is on genetics, neurobiological and ecological aspects are also included to provide intellectual breadth. The book uses examples that span the gamut from classical model organisms to non-model systems and human biology, and include both laboratory and field studies. Samples of historical information accentuate the text to provide the reader with an appreciation of the history of the field.
This book will be a valuable resource for future generations of scientists who focus on the field of behavioral genetics.
Inhaltsverzeichnis zu „Principles of Behavioral Genetics “
PrefaceChapter 1: Introduction and Historical Perspective
Overview
The Rise of the Modern Field of Behavioral Genetics
The Modern Evolutionary Synthesis
The Rise of Molecular Genetics
A Brief History of Neuroscience
The Emergence of Behavioral Genetics
Summary
Study Questions
Recommended Reading
Chapter 2: Mechanisms of Neural Communication
Overview
Transmission of Information in the Nervous System
The Resting Membrane Potential
The Mechanism of the Action Potential
Ion Channels, G-protein-coupled Receptors, and Signal Transduction
Summary
Study Questions
Recommended Reading
Chapter 3: Functional Organization of the Nervous System
Overview
The Organization of the Mammalian Nervous System
Communication between the Brain and the Periphery
Organization of the Nervous System in Insects
Neurotransmitters
Summary
Study Questions
Recommended Reading
Chapter 4: Measuring Behavior: Sources of Genetic and Environmental Variation
Overview
Behavioral Assays
Controlling Experimental Variation
Sources of Variation in Behavior
Effects of Mutations on Behavioral Phenotypes
Environmental Variation
Gene - Environment Correlation and Interaction
Summary
Study Questions
Recommended Reading
Chapter 5: Mapping Genotype to Phenotype in Populations
Overview
Genes in Populations: Random Mating
Genes in Populations: Inbreeding
Quantitative Genetic Model
Summary
Study Questions
Recommended Reading
Chapter 6: Partitioning Phenotypic Variance and Heritability
Overview
Components of Variance in Random Mating Populations
Genotype-Environment Correlation and Interaction
Partitioning Phenotypic Variance
Heritability : The Concept
Controlling and Estimating Environmental Components of Variation
Summary
Study Questions
Recommended Reading
Chapter 7: Estimating Heritability
... mehr
Overview
Phenotypic Resemblance between Relatives
Genetic Causes of Covariance between Relatives
Environmental Causes of the Relationship between Relatives
Heritability Estimates in Humans
Heritability in Other Populations
Estimates of Heritability for Behavioral Traits
Summary
Study Questions
Recommended Reading
Chapter 8: Quantitative Trait Locus Mapping
Overview
Linkage Mapping
Interval Mapping
Statistical Analysis
Association Mapping
Quantitative Trait Locus End Game
Summary
Study Questions
Recommended Reading
Chapter 9: Mutagenesis and Transgenesis
Overview
The Occurrence or Induction of Mutations
Homologous Recombination
Transposon -mediated Mutagenesis
The GAL4-UAS Binary Expression System in Drosophila
RNA Interference
Summary
Study Questions
Recommended Reading
Chapter 10: Genomics Approaches in Behavioral Genetics
Overview
Detecting Large-scale Gene Expression
Parallel Sequencing and Transcriptional Analysis
Plasticity of Transcriptional Profiles
Analysis of Whole-genome Expression Microarray
Defining Statistical Signifi cance Threshold
Identifying Genetic Networks
Summary
Phenotypic Resemblance between Relatives
Genetic Causes of Covariance between Relatives
Environmental Causes of the Relationship between Relatives
Heritability Estimates in Humans
Heritability in Other Populations
Estimates of Heritability for Behavioral Traits
Summary
Study Questions
Recommended Reading
Chapter 8: Quantitative Trait Locus Mapping
Overview
Linkage Mapping
Interval Mapping
Statistical Analysis
Association Mapping
Quantitative Trait Locus End Game
Summary
Study Questions
Recommended Reading
Chapter 9: Mutagenesis and Transgenesis
Overview
The Occurrence or Induction of Mutations
Homologous Recombination
Transposon -mediated Mutagenesis
The GAL4-UAS Binary Expression System in Drosophila
RNA Interference
Summary
Study Questions
Recommended Reading
Chapter 10: Genomics Approaches in Behavioral Genetics
Overview
Detecting Large-scale Gene Expression
Parallel Sequencing and Transcriptional Analysis
Plasticity of Transcriptional Profiles
Analysis of Whole-genome Expression Microarray
Defining Statistical Signifi cance Threshold
Identifying Genetic Networks
Summary
... weniger
Autoren-Porträt von Robert R.H. Anholt, Trudy F. C. Mackay
Robert R.H. Anholt works in the W.M. Keck Center for Behavioral Biology at North Carolina State University, Raleigh, NC, USA
Bibliographische Angaben
- Autoren: Robert R.H. Anholt , Trudy F. C. Mackay
- 2009, 334 Seiten, Maße: 21,3 x 27,4 cm, Kartoniert (TB), Englisch
- Verlag: Academic Press
- ISBN-10: 0123725755
- ISBN-13: 9780123725752
- Erscheinungsdatum: 04.11.2009
Sprache:
Englisch
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