Principles of Molecular Rheumatology
(Sprache: Englisch)
George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established...
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Klappentext zu „Principles of Molecular Rheumatology “
George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.
Inhaltsverzeichnis zu „Principles of Molecular Rheumatology “
Part I. Molecular Mechanisms in Rheumatic Diseases- Genetics
- Viruses
- Apoptosis
- Humoral Response
- T-Cell Signaling
- Adhesion and Costimulatory Molecules
- Transcription Factors
- Immune Complexes
- Complement
- Eicosanoids and Other Bioactive Lipids
- Collagens
Part II. Cellular Mechanisms in Rheumatic Diseases
- T-Lymphocytesr
- B-Lymphocytes
- Monocytes and Macrophagesl
- Polymorphonuclear Cells
- Synoviocytes
- Chondrocytes
- Osteoblasts and Osteoclasts
- Animal Models
Part III. Pathogenesis of Rheumatic Diseases
- Systemic Lupus Erythematosus
- Rheumatoid Arthritis
- Inflammatory Myopathies
- Systemic Sclerosis
- Vasculitis
- Osteoarthritis
- Osteoporosis
- Heritable Disorders of Connective Tissue
Part IV. Molecular Aspects of Treatment of Rheumatic Diseases
- Corticosteroids
- Cytotoxic Drugs
- Complement Inhibitors
- Cytokine Response Modifiers
- Restoration of Immune Tolerance
- Metalloproteases and Their Modulation as Treatment in Osteoarthritis
- Gene Therapy
- Index
Bibliographische Angaben
- 2000, 2000, 542 Seiten, Maße: 18,3 x 26 cm, Gebunden, Englisch
- Herausgeber: Tsokos, George C.
- Herausgegeben: George C. Tsokos
- Verlag: Springer
- ISBN-10: 0896037738
- ISBN-13: 9780896037731
- Erscheinungsdatum: 24.07.2000
Sprache:
Englisch
Rezension zu „Principles of Molecular Rheumatology “
"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal"It contains many figures of good quality." - Journal of Endocrine Genetics"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing
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