Protein Degradation

Degrons: signals and sites for ubiquitylation

The proteasome portal and regulation of proteolysis

PAN and the proteasome

Ubiquitin domain proteins

MEKK1: dual function as a protein kinase and a ubiquitin protein ligase

HECT domain ubiquitin protein ligases

UCRP: ubiquitin cross-reactive protein

SUMOs and their function in the cell

Functions of the ubiquitin-proteasome pathway

Molecular Chaperones and the ubiquitin/proteasome system

Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes

Electron microscopy of compartmentalised proteases

Molecular dissection of autophagy in yeast

John Mayer obtained his MS and PhD degrees from the University of Birmingham (UK). He is currently serving as Professor of Biochemistry at the School of Biomedical Sciences at Nottingham University.

For the past 30 years, he has investigated intracellular proteolysis and particularly the ubiquitin/proteasome system. Presently, he is particularly interested in intracellular proteolysis in relation to neurodegenerative illnesses.

Aaron Ciechanover obtained his MD from the Hebrew University in Jerusalem (Israel), and his PhD from the Technion-Israel Institute of Technology in Haifa, where he is presently serving as Professor of Biochemistry. Professor Ciechanover is known for his discovery of the first ubiquitin system mutant cell, demonstrating the role of the ubiquitin-proteasome proteolytic system in protein degradation in vivo. His present work aims to elucidate the mode of recognition of specific target substrates and the role of the ubiquitin-proteasome system in the degradatio of nuclear oncoproteins and in activation and elimination of transcription factors.

In 2004, he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system.

Martin Rechsteiner is Professor of Biochemistry at the University of Utah in Salt Lake City (USA). He is interested in the proteasome component of the ubiquitin-proteasome pathway. He has identified several key regulators of proteasome function and is currently working on their structural and functional elucidation.

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