Protein Kinase CK2 - From Structure to Regulation

Characterization of CK2 holoenzyme variants with regard to crystallization.- Generation of mutants of CK2? which are dependent on the ?-subunit for catalytic activity.- Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners.- A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin.- The activity of CK2 in the extracts of COS-7 cells transfected with wild type and mutant subunits of protein kinase CK2.- Transcriptional coordination of the genes encoding catalytic (CK2?) and regulatory (CK2?) subunits of human protein kinase CK2.- Genes targeted by protein kinase CK2: A genome-wide expression array analysis in yeast.- Consequences of CK2 signaling to the nuclear matrix.- Localization of individual subunits of protein kinase CK2 to the endoplasmic reticulum and to the Golgi apparatus.- Visualization and molecular analysis of nuclear import of protein kinase CK2 subunits in living cells.- Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2.- A gene located at 72A in Drosophila melanogaster encodes a novel zinc-finger protein that interacts with protein kinase CK2.- Environmental reprogramming of the expression of protein kinase CK2? subunit in fish.- Mutation at the CK2 phosphorylation site on Cdc28 affects kinase activity and cell size in Saccharomyces cerevisiae.- Distinctive features of plant protein kinase CK2.- Cloning and characterization of the cDNA coding for the catalytic ? subunit of CK2 from tobacco.- Regulation of the human papillomavirus oncoproteins by differential phosphorylation.- HIV-1 Rev transactivator: A ?-subunit directed substrate and effectorof protein kinase CK2.- Protein kinase CK2: Signaling and tumorigenesis in the mammary gland.- Response of cancer cells to molecular interruption of the CK2 signal.- The genomic structure of two protein kinase