Protein-Ligand Interactions

Frontmatter -- Preface -- Section I. General -- Letter from J. Wyman to the Members of the Symposium -- Concerted Changes in an Allosteric Macromolecule -- Ligand Interactions in Globular Proteins -- Discussion -- Ligand Binding to Enzyme Complexes -- Discussion -- Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography -- Discussion -- Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes -- Discussion -- Section II. Enzymes -- The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis -- Discussion -- The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog -- Discussion -- The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin -- Discussion -- Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes -- Discussion -- On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600 -- Discussion -- The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity -- Discussion -- Cooperative Interactions without Symmetry or Subunits -- Discussion -- A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A -- Discussion -- Section III. Repressors -- Lactose Operator Sequences and the Action of Lac Repressor -- Discussion -- The Active Sites of Lac Repressor -- Discussion -- Lac Repressor -- Discussion -- The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules -- Discussion -- Effect of Alterations in Lac Operator DNA on Repressor Binding -- Discussion -- Interaction of Lac Repressor with Non-Specific DNA Binding Sites -- Discussion -- Section IV. Receptors -- Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata -- Discussion -- Subunit Structure and Binding Sites of the Acetylcholine Receptor --