Pulmonary Arterial Hypertension
Diagnosis and Evidence-Based Treatment
(Sprache: Englisch)
Pulmonary hypertension is frequently misdiagnosed and has often progressed to a late stage by the time it is accurately diagnosed. It has therefore long been considered untreatable and incurable with an overall very poor survival rate. However, new...
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Klappentext zu „Pulmonary Arterial Hypertension “
Pulmonary hypertension is frequently misdiagnosed and has often progressed to a late stage by the time it is accurately diagnosed. It has therefore long been considered untreatable and incurable with an overall very poor survival rate. However, new treatments are now available which have significantly improved prognosis. Recent data demonstrate survival is continuing to improve, with patients living for fifteen to twenty years or longer after diagnosis with an overall good quality of life.In this work, each chapter will discuss therapeutic options with reference to the pre clinical studies which provided the rationale for their clinical development. The book will also include evidence-based treatment algorithms based on the 2007 update of the ACCP Guidelines for Medical Treatment of Pulmonary Hypertension.
Aimed at specialists in pulmonary and cardiovascular disease, this volume provides the clinician with the most up to date information on the effective management of pulmonary hypertension.
Pulmonary hypertension is frequently misdiagnosed and has often progressed to a late stage by the time it is accurately diagnosed. It has therefore long been considered untreatable and incurable with an overall very poor survival rate. However, new treatments are now available which have significantly improved prognosis. Recent data demonstrate survival is continuing to improve, with patients living for fifteen to twenty years or longer after diagnosis with an overall good quality of life.
In this work, each chapter will discuss therapeutic options with reference to the pre clinical studies which provided the rationale for their clinical development. The book will also include evidence-based treatment algorithms based on the 2007 update of the ACCP Guidelines for Medical Treatment of Pulmonary Hypertension.
Aimed at specialists in pulmonary and cardiovascular disease, this volume provides the clinician with the most up to date information on the effective management of pulmonary hypertension.
In this work, each chapter will discuss therapeutic options with reference to the pre clinical studies which provided the rationale for their clinical development. The book will also include evidence-based treatment algorithms based on the 2007 update of the ACCP Guidelines for Medical Treatment of Pulmonary Hypertension.
Aimed at specialists in pulmonary and cardiovascular disease, this volume provides the clinician with the most up to date information on the effective management of pulmonary hypertension.
Inhaltsverzeichnis zu „Pulmonary Arterial Hypertension “
PrefaceContributors
1 Introduction (Robyn J. Barst)
2 Diagnosis and assessment of pulmonary arterial hypertension (Michael D. McGoon, Adam Torbicki and Ronald J. Oudiz)
2.1 Hemodynamics of pulmonary hypertension
2.2 Venice classification
2.3 Overview of the diagnostic process (algorithm)
2.4 Screening (identifying a pre-existing risk)
2.5 Detection (discovering pulmonary hypertension)
2.6 Definition (diagnosing the clinical context)
2.7 Prediction (estimating prognosis)
2.8 Principles of follow-up (evaluating and responding to outcome)
2.9 Specific tests in the evaluation of pulmonary hypertension
3 Conventional therapy in pulmonary arterial hypertension (Richard N. Channick)
3.1 Calcium channel antagonists
3.2 Diuretics
3.3 Warfarin
3.4 Supplemental oxygen
3.5 Inotropic therapy
3.6 General measures
3.7 Conclusions
4 Prostanoid treatment for pulmonary arterial hypertension (Olivier Sitbon and Gérald Simonneau)
4.1 Epoprostenol
4.2 Treprostinil
4.3 Iloprost
4.4 Beraprost
4.5 Treatment selection
4.6 Conclusions
5 Endothelin receptor antagonists in pulmonary arterial hypertension (David B. Badesch and Marc Humbert)
5.1 Bosentan
5.2 Sitaxsentan
5.3 Ambrisentan
5.4 Safety and tolerability with endothelin receptor antagonists
5.5 Conclusions
6 Phosphodiesterase-5 inhibitors in pulmonary arterial hypertension (Hossein A. Ghofrani, Werner Seeger and Friedrich Grimminger)
6.1 The origins of phosphodiesterase-5 inhibitor development
6.2 Pulmonary hypertension as a new indication for phosphodiesterase-5 inhibitor treatment
6.3 Role of phosphodiesterase-5 in the pulmonary vasculature
6.4 Clinical experience with sildenafil for the treatment of chronic pulmonary hypertension
6.5 Pivotal trial and approval of sildenafil for the treatment of pulmonary arterial hypertension (SUPER-1 study)
6.6 Other phosphodiesterase-5 inhibitors
6.7 Combination therapy
6.8 Potential new indications for phosphodiesterase-5
... mehr
inhibitors outside pulmonary arterial hypertension
6.9 Conclusions
7 Combination therapy for pulmonary arterial hypertension (Anne Keogh and Marius Hoeper)
7.1 Background
7.2 Combination therapy to date
7.3 Conclusions
8 Interventional and surgical modalities of treatment for pulmonary arterial hypertension (Julio Sandoval and Ramona Doyle)
8.1 Introduction
8.2 Atrial septostomy
8.3 Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension
8.4 Lung transplantation for pulmonary hypertension
8.5 Conclusions
9 End points and clinical trial design in pulmonary arterial hypertension: Clinical and regulatory perspectives (Andrew J. Peacock)
9.1 Introduction
9.2 Trial design
9.3 End points in trials of therapy for pulmonary arterial hypertension
9.4 Conclusions
10 Comparative analysis of clinical trials and evidence-based treatment algorithm for pulmonary arterial hypertension (Nazzareno Galiè, Alessandra Manes, Naushad Hirani and Robert Naeije)
10.1 Introduction
10.2 Randomized controlled studies
10.3 Long-term continuation studies
10.4 Combination studies
10.5 Evidence-based treatment algorithm
10.6 Conclusions
11 Diagnosis and assessment of non-pulmonary arterial hypertension masquerading as idiopathic pulmonary arterial hypertension: Diastolic heart failure - evaluation and interactions (Mardi Gomberg-Maitland and Stuart Rich)
11.1 Definition of heart failure
11.2 Epidemiology
11.3 Physiology
11.4 Evaluation of diastolic heart failure: Invasive and noninvasive techniques
11.5 Diagnosis and treatment of diastolic dysfunction
11.6 Pulmonary hypertension and diastolic dysfunction
11.7 Conclusions
12 Treatment of pulmonary arterial hypertension: A look to the future (Lewis J. Rubin)
12.1 Therapy of pulmonary arterial hypertension
12.2 Measuring outcomes and monitoring the course of therapy
12.3 Conclusions
Index
6.9 Conclusions
7 Combination therapy for pulmonary arterial hypertension (Anne Keogh and Marius Hoeper)
7.1 Background
7.2 Combination therapy to date
7.3 Conclusions
8 Interventional and surgical modalities of treatment for pulmonary arterial hypertension (Julio Sandoval and Ramona Doyle)
8.1 Introduction
8.2 Atrial septostomy
8.3 Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension
8.4 Lung transplantation for pulmonary hypertension
8.5 Conclusions
9 End points and clinical trial design in pulmonary arterial hypertension: Clinical and regulatory perspectives (Andrew J. Peacock)
9.1 Introduction
9.2 Trial design
9.3 End points in trials of therapy for pulmonary arterial hypertension
9.4 Conclusions
10 Comparative analysis of clinical trials and evidence-based treatment algorithm for pulmonary arterial hypertension (Nazzareno Galiè, Alessandra Manes, Naushad Hirani and Robert Naeije)
10.1 Introduction
10.2 Randomized controlled studies
10.3 Long-term continuation studies
10.4 Combination studies
10.5 Evidence-based treatment algorithm
10.6 Conclusions
11 Diagnosis and assessment of non-pulmonary arterial hypertension masquerading as idiopathic pulmonary arterial hypertension: Diastolic heart failure - evaluation and interactions (Mardi Gomberg-Maitland and Stuart Rich)
11.1 Definition of heart failure
11.2 Epidemiology
11.3 Physiology
11.4 Evaluation of diastolic heart failure: Invasive and noninvasive techniques
11.5 Diagnosis and treatment of diastolic dysfunction
11.6 Pulmonary hypertension and diastolic dysfunction
11.7 Conclusions
12 Treatment of pulmonary arterial hypertension: A look to the future (Lewis J. Rubin)
12.1 Therapy of pulmonary arterial hypertension
12.2 Measuring outcomes and monitoring the course of therapy
12.3 Conclusions
Index
... weniger
Bibliographische Angaben
- 2008, 1. Auflage, 264 Seiten, Maße: 24,5 cm, Gebunden, Englisch
- Herausgegeben: Robyn Barst
- Verlag: Wiley & Sons
- ISBN-10: 0470059729
- ISBN-13: 9780470059722
- Erscheinungsdatum: 03.06.2008
Sprache:
Englisch
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