Pulmonary Hypertension

Historical Perspective on the Classification and Nomenclature of Pulmonary Hypertension.- The Defining Characteristics of Pulmonary Arterial Hypertension.- Pulmonary Hypertension in Patients Without Pulmonary Arterial Hypertension.- Epidemiology of Pulmonary Hypertension: From Quaternary Referral Centre to the Community.- The Effects of Chronic Hypoxia on Inflammation and Pulmonary Vascular Function.- Genetics of Pulmonary Vascular Disease.- Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary Hypertension.- Pulmonary Hypertension as a Metabolic Disease.- Renin-Angiotensin-Aldosterone and other Neurohumoral Factors in the Pathogenesis of Pulmonary Hypertension.- Animal Models of Pulmonary Hypertension.- The Cardiopulmonary Hemodynamic Evaluation of Pulmonary Hypertension.- Advanced Imaging in Pulmonary Hypertension.- Assessing Disease State in the Pulmonary Vasculature in Clinical Practice and Research.- Biomarkers and other Methods for Assessing Patient Progress.- Pulmonary Circulatory - Right Ventricular Uncoupling: New Insights into Pulmonary Hypertension Pathophysiology.- Contemporary Pharmacotherapies Involving Nitric Oxide, Prostacyclin, and Endothelin Receptor Signaling Pathways.- Determining the Optimal Approach to Initiating Oral, Inhaled, and Intravenous Therapies in Clinical Practice: Sequential Goal-Directed Therapy is Best.- Counterpoint: Determining the optimal approach to initiating oral, inhaled, and intravenous therapies in clinical practice: Maximal upfront therapy is best.- Surgery, Devices, Transplantation and Other Interventional Options for the Treatment of Advanced Pulmonary Hypertension.- Patient Registries in Pulmonary Arterial Hypertension: the Role of Survival Equations and Risk Calculators.- Support Care for the Pulmonary Hypertension Patient.- Special Considerations for the Pulmonary Hypertension Patient.- The Future of Pulmonary Hypertension.

Bradley A. Maron, MD completed his fellowship in cardiovascular medicine at Brigham and Women's Hospital in 2011 before joining the Faculty at BWH and Harvard Medical School in 2012. His work has recently contributed to the identification of aldosterone as a potentially modifiable factor in the pathogenesis of pulmonary arterial hypertension. Dr. Maron is the recipient of the prestigious Lerner Foundation Award and Klarman Foundation Award at Harvard Medical School. Hunter Champion, M.D., Ph.D. joined the faculty of the Division of Pulmonary, Allergy and Critical Care Medicine, the Vascular Medicine Institute and the Cardiovascular Institute at the University of Pittsburgh in 2009 as an Associate Professor of Medicine. He directs Translational Research for the University of Pittsburgh Vascular Medicine Institute and the Pulmonary Vascular Disease Center. His research has spanned basic and clinical science work on mechanisms of pulmonary hypertension. He is the recipient of the American Physiological Society Shin Chun Wang Young Investigator Award, the Giles F. Filley Young Investigator Award as well as the Young Investigator Award from the Cardiopulmonary Council of the AHA, and The Zipes Distinguished Young Investigator Award by the American College of Cardiology. He is a founding member of the Pulmonary Vascular Research Institute. Aaron B. Waxman, M.D., Ph.D. is an Associate Professor of Medicine at Harvard Medical School with appointments in the Division's of Pulmonary Critical Care Medicine and Cardiovascular Medicine. His interests have focused on developing a translational center that integrates clinical and basic research and focuses on a better understanding of the pathogenesis of pulmonary vascular remodeling and the physiology of right ventricular adaptation to changes in the pulmonary vascular bed. A direct product of this program is the newly organized Dyspnea and Performance Evaluation Center at the Brigham and Women's Hospital.

"This is a comprehensive book on the important clinical topic of pulmonary hypertension, and one of the most up to date on this emerging field of study. ... The intended audience is specialists in the field of cardiology and pulmonology. ... This book is useful for both clinicians and those interested in basic science and translational research." (Shubhum Misra, Doody's Book Reviews, February, 2016)