Purine and Pyrimidine Metabolism in Man VI

Spectrum of HPRT Deficiency: An Update.- Lesch-Nyhan Syndrome due to a Single Nucleotide Change in the Hypoxanthine-Guanine Phosphoribosyltransferase Gene (HGPRT Yale).- Structural Consequences of Point Mutations in Nine Human HPRT Variants.- Lesch-Nyhan Syndrome and HPRT Variants: Study of Heterogeneity at the Gene Level.- Characterization of Genomic DNA, mRNA and Enzyme Protein in Cases of HPRT Deficiency.- Is HPRT-like Protein Present in Lesch-Nyhan Patients?.- Lesch-Nyhan Syndrome: Reduced Amino Acid Concentrations in CSF and Brain.- Hypoxanthine Accumulation and Dopamine Depletion in Lesch-Nyhan Disease.- Hypoxanthine and Xanthine Transport through the Blood-Brain Barrier in Hypoxanthine Phosphoribosyltransferase (HPRT) Deficiency.- Cerebrospinal Fluid Cyclic Nucleotide Alterations in the Lesch-Nyhan Syndrome.- Purine Nucleotide Restration in HPRT* Cells.- Gout and Uric Acid.- Clinical Aspects of Gouty Patients in Taiwan.- Can Risk Scores for Vascular Disease in Gout Patients Be Improved?.- A Model of Gout Nephropathy.- Hyperuricemia, Gout and Idiopathic Aseptic Necrosis of Bone.- The Solubility of Uric Acid and Monosodium Urate in Urine.- A Role of lnterleukin-1 (IL-1) in Crystal-Induced Arthritis.- Is Gout Related to an Alteration of the Uric Acid Protein Binding?.- Urate Binding Globulin, Interactions with Immunoglobulins.- Behavior of Oxypurines in Normal Subjects After an 8 Day Purine-Free Diet.- Should Dietary Restrictions Always Be Prescribed in the Treatment of Gout?.- Activity and Effect of Purine Metabolizing Enzymes in the Digestive Tract.- Intermittent Control of Hyperuricaemia in the Treatment of Gout.- The Allopurinol Hypersensitivity Syndrome: Its Relation to Plasma Oxipurinol Levels.- Fungalbionics: A New Concept of the Etiology of Gout, Hyperuricemia and their Related Diseases.- Renal Handling of Oxypurines.- Impaired Renal Excretion of Hypoxanthine and Xanthine in Primary Gout.- Renal Excretions of Oxypurinol and Oxypurines - Effects of Pyrazinamide, Probenecid and Benzbromarone.- Renal Excretion of Purine Bases - Effects of Probenecid, Benzbromarone and Pyrazinamide.- Hyperuricemia and Gout in Cyclosporin A-Treated Renal Transplant Recipients.- Stop-Flow Studies on Tubular Transport of Uric Acid in Rats.- The Activity of AA-193, A New Uricosuric Agent, in Animals.- Renal Handling of Hypoxanthine and Xanthine in Normal Subjects and in Cases of Idiopathic Renal Hypouricemia.- Nucleotide Catabousm.- D-Xylulose-Induced Depletion of ATP and Pi and Increase in PRPP in Isolated Rat Hepatocytes.- Red Blood Cell Morphology in Chronic Obstructive Pulmonary Disease: Effect of Oxygen Therapy versus Allopurinol.- Enhanced Adenine Nucleotide Degradation in Chronic Obstructive Pulmonry Disease: The Effect of Oxygen Therapy.- Purine Metabolism as Measures of Birth Asphyxia and Predictors of Brain Damage.- Erythrocyte ATP (iATP) as an Indicator of Neonatal Hypoxia.- Degradation of Purine Nucleosides by Mitochndrial Enzymes of Bovine Liver.- AMP Catabolism in Primary Rat Cardimyocyte Cultures.- Muscle and Purine Metabolsim.- Purine Degradation in Contracting Fast and Slow Muscles of Rats.- Persistent Production of Hypoxanthine in Rat Skeletal Muscle Causes Prolonged Hyperuricemia after an Enhaustice Exercise.- Exercise Induced Alteration of Erythrocyte Glycolysis Associated with Myogenic Hyperuricemia.- Myogenic Hyperuricemia: a Comparative Study between Type V and Type VII Glycogenosis.- Purine Metabolism in Human Tissue.- Uric Acid and Purine Compounds in Aortic and Coronary Sinus Blood in Man.- Purine Catabolic Enzymes in Human Synovial Fluids.- Changes in Trophoblastic Purine Metabolism with Aging of the Placenta.- Evaluation of Oxypurines by HPLC in Lymphoproliferative Diseases.- Chemiluminescent Assays in the Study of Purine Metabolism.- Isozyme Shift of Adenylosuccinate Synthase in Rat and Huamn Neoplasms.- Purine Nucleotide Synthesis during Terminal Differentiation.- Anti-Cancer Purine and Pyrimidine Analogs Cunical Aspects.- Activity of 2-Chloro-2?-Deoxyadenosine in Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and Autoimmune Hemolytic Anemia.- Purine and Pyrimidine Metabolism of Normal and Leukemic Lymphocytes.- In Vitro and In Vivo Inhibition of Thymidylate Synthase of Human Colon Cancer by 5-Fluorouracil.- Sensitivity to Purine Analogues in Childhood Leukemia Assessed by the Automated MTT-Assay.- Selective Inhibition of Cytotoxic T Lymphocyte Proliferation by Mizoribine (Bredinin), an Adenosine Analog.- Molecular Genetics of Purine and Pyrimidine Enzymes.- Restriction Fragment Length Polymorphisms of HPRT and APRT Genes in Japanese Population.- An Analysis of 5? Regulatory Sequences of the Hamster APRT Gene.- Effect of Alterations of the ATG Translation Start Codon of the APRT Gene.- Sequencing of Mammalian Messenger RNA Using Oligonucleotide Primers: Application to Hypoxanthine Phosphoribosyltransferase and a Phosphoglycerate Kinase Variant.- Molecular Aspect of Myogenic Hyperuricemia: Cloning of Human Muscle Phosphofructokinase cDNA.- Autosomal Dominant Hemolytic Anemia and Adenosine Deaminase Overproduction.- Cloning the Full-Length cDNA for the Porcine Urate Oxidase by the MOPAC Generated Probe.- Sequence Analysis of Rat Liver Uricase-cDNA and the Possible Presence of the Homologous cDNA Sequences in Chicken Embryo.- Molecular Cloning of Human UMP Synthase.- Deduced Amino Acid Sequence from Human Phosphoribosylpyrophosphate Synthetase Subunit II cDNA.- Analysis of Molecular Structure of Rat Phosphoribosylpyrophosphate Synthetase Genes.- Approaches to the Gene Therapy.- Controllable Expression of an E. Coli Amidophosphoribosyltransferase (ATase) Gene in ATase-Deficient Mammalian Fibroblasts- a Basic Model for Gene Therapy.- Two Types of Mouse FM3A Cell Mutants Deficient in 5-Aminoimidazole-4-Carboxamide Ribonucleotide Transformylase and their Transformants Isolated by Human Chromosome-Mediated Gene Transfer.- Immunological and Metabolic Reconstitution Following Successful Bone Marrow Transplantation from a HLA-Identical Sibling in an Infant with Adenosine Deaminase Deficeincy and Severe Combined Immunodeficiency: Partial Restoration of Purine Metabolism.- Transfer of Human HPRT Gene Sequence into Neuronal Cells by a Herpes Simplex Virus Derived Vector.- Contributors.