Real World Drug Discovery

1 The Drug Discovery Business to Date
2 The Drug Discovery Business to Come
3 Industrial Considerations
4 How Things Get Done: The Project Team
5 Project Considerations
6 Hit Generation
7 Turning Hits into Drugs
8 Initial Properties
9 ADME and PK Properties
10 Toxicity-Related Properties
11 A Career in Drug Discovery

Over 24 years experience in industry including positions at: Celera Genomics, Gensia Pharmaceuticals, Syntex Corporation, Shell Development and G.D. Searle and Company.



Author of 21 papers, 12 patent applications and 2 book chapters.

BRITISH TOXICOLOGY SOCIETY NEWSLETTER, Summer 2010 issue: "[I]lluminating and stimulating, as the author uses examples to demonstrate how the challenge of making new, profitable, drugs has changed in the last few years, as well as the shape of pharmaceutical companies themselves. The relaxed writing-style of the author makes this book both very easy to read and enjoyable, while at the same time peppering the reader with new facts. Whereas the book is labeled as a chemist's guide, I suspect that it would be of use to many people entering the drug discovery arena, be they chemists or not. Robert Rydzewski has succeeded in producing a text that will find its way onto the shelves of many early career-stage scientists, and I think they will be considerably improved by reading it." - Nick Plant, Centre for Toxicology, University of Surrey, UK JOURNAL OF MEDICINAL CHEMISTRY, Volume 53, number 4: As explained in his preface, the purposes of [the author's] treatise are to present new researchers "with a basic overview of how modern industrial drug discovery works", to introduce the relevant scientific disciplines, and "to provide some practical insights into common problems in drug discovery", and possible solutions. In my opinion, he has achieved these goals in an excellent manner. .This book is enthusiastically recommended to graduate faculty and students, to postdocs, recent graduates, young workers in the pharma industry, to anyone who would like a one-volume review of modern industrial drug discovery, and to the libraries that serve these groups. - Manfred E. Wolff, Intellepharm, Inc. CHOICE, April 2009: "More than a primer, this book serves as an excellent introduction to research in industry in general and the pharmaceutical industry in particular, as well as a career resource ... Of particular interest to chemistry graduate students as well as research-orientated undergraduates and their mentors. Summing Up: Highly recommended." - R. E Buntrock, formerly, University

BRITISH TOXICOLOGY SOCIETY NEWSLETTER, Summer 2010 issue: "[I]lluminating and stimulating, as the author uses examples to demonstrate how the challenge of making new, profitable, drugs has changed in the last few years, as well as the shape of pharmaceutical companies themselves.. The relaxed writing-style of the author makes this book both very easy to read and enjoyable, while at the same time peppering the reader with new facts. Whereas the book is labeled as a chemist's guide, I suspect that it would be of use to many people entering the drug discovery arena, be they chemists or not. Robert Rydzewski has succeeded in producing a text that will find its way onto the shelves of many early career-stage scientists, and I think they will be considerably improved by reading it." - Nick Plant, Centre for Toxicology, University of Surrey, UK

JOURNAL OF MEDICINAL CHEMISTRY, Volume 53, number 4: As explained in his preface, the purposes of [the author's] treatise are to present new researchers "with a basic overview of how modern industrial drug discovery works", to introduce the relevant scientific disciplines, and "to provide some practical insights into common problems in drug discovery", and possible solutions. In my opinion, he has achieved these goals in an excellent manner. .This book is enthusiastically recommended to graduate faculty and students, to postdocs, recent graduates, young workers in the pharma industry, to anyone who would like a one-volume review of modern industrial drug discovery, and to the libraries that serve these groups. - Manfred E. Wolff, Intellepharm, Inc.