Redox Regulation and Therapeutic Approaches in Cancer

Chapter 1_ROS, redox regulation and signaling in cancer cells. -Chapter 2_ROS and redox regulation/signaling in cancer stem cells and metabolism. - Chapter 3_ROS/Redox regulation with dietary phytochemicals and role in anticancer activity. -Chapter 4_ROS/Redox signaling and apoptosis/necrptosis/autophagy in cancer. - Chapter 5_Cancer Metastasis, ROS/redox signaling and PCD resistance/redox metabolism. - Chapter 6_ Immune system, redox signaling and cancer immunity. - Chapter 7_P53, ROS- redox regulation signaling, metabolic reprogramming and autophagy in cancer. - Chapter 8_Cell cycle, DNA damage-repair systems and impact of redox regulation in cancer. - Chapter 9_ ROS, redox regulation and anticancer therapy. - Chapter 10_Perspectives in ROS/redox regulation cancer therapy.

Dr Mohinder Pal Bansal did MSc (Honours) in Biophysics in 1972 and PhD in 1980 on carcinogenesis from Department of Biophysics, Panjab University, Chandigarh (India). He worked as a faculty member since 1978 in the above department and superannuated in 2008 as professor. Main subject taught were Mammalian Physiology, Basic Molecular Biology, and Gene & Protein Engineering. After superannuation, he worked as emeritus fellow/scientist sponsored by UGC and ICMR for five years. During sabbaticals he has also worked as Research Associate and Visiting Faculty at the prestigious institution Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA. During this period, he has worked on the isolation and characterization of selenoproteins (having anticancer activity) and published work in reputed scientific journals. His core area of the research involved molecular pathophysiology under the influence of experimental oxidative stress and its modulation in spermatogenesis, atherosclerosis and carcinogenesis. Regulation of gene expression related to the endogenous antioxidative enzymes, transcription factors and their upstream activators (MAP kinases) were studied at transcriptional and translational level using RT-PCR and immunohistochemistry/ELISA etc.



He was listed as reviewer for various international research journals. Out of his total 114 research publications, many are in the peer-reviewed national and international journals. He has authored two books, one as single author and another shared.