Separation of Enantiomers

INTRODUCTION: A SURVEY OF HOW AND WHY TO SEPARATE ENANTIOMERSClassical MethodsKinetic Resolution ('KR')Dynamic Kinetic Resolution ('DKR')Divergent Reactions of a Racemic Mixture ('DRRM')Other MethodsSTOICHIOMETRIC KINETIC RESOLUTION REACTIONSIntroductionKinetic TreatmentChiral Reagents and Racemic SubstratesEnantiodivergent Formation of Chiral ProductEnantioconvergent ReactionsDiastereomer Kinetic ResolutionSome Applications of Kinetic ResolutionConclusionCATALYTIC KINETIC RESOLUTIONIntroductionKinetic Resolution of AlcoholsKinetic Resolution of EpoxidesKinetic Resolution of AminesKinetic Resolution of AlkenesKinetic Resolution of Carbonyl DerivativesKinetic Resolution of Sulfur CompoundsKinetic Resolution of FerrocenesConclusionsAPPLICATION OF ENZYMES IN KINETIC RESOLUTIONS, DYNAMIC KINETIC RESOLUTIONS AND DERACEMIZATION REACTIONSIntroductionKinetic Resolutions Using Hydrolytic EnzymesDynamic Kinetic ResolutionDeracemizationEnantioconvergent ReactionsConclusionsDYNAMIC KINETIC RESOLUTION (DKR)IntroductionDefinition and ClassificationDynamic Kinetic Resolution (DKR)Mathematical ExpressionDKR-Related MethodsConcluding RemarksENANTIODIVERGENT REACTIONS: DIVERGENT REACTIONS ON A RACEMIC MIXTURE AND PARALLEL KINETIC RESOLUTIONIntroduction: The Conceptual Basis for Kinetic Resolution and Enantiodivergent ReactionsDivergent RRM Using a Single Chiral Reagent: Ketone ReductionDivergent RRM under Oxidative ConditionsOrganometallic Reactions and Regiodivergent RRMRegiodivergent RRM in Selective Reactions of Difunctional SubstratesDivergent RRM Using Two Chiral Reagents: Parallel Kinetic Resolution (PKR)ConclusionRARE, NEGLECTED AND POTENTIAL SYNTHETIC METHODS FOR THE SEPARATION OF ENANTIOMERSResolution through the Selfish Growth of Polymers: Stereoselective PolymerizationResolution through Photochemical MethodsCombinations of Crystallization and RacemizationDestruction then Recreation of Stereocentres: Enantioselective ProtonationsDynamic Combinatorial ChemistryAsymmetric

An Associate Professor at The University of Sydney's School of Chemistry, Matthew Todd gained his BA and PhD from Cambridge University, UK, where he later became a Fellow in Chemistry. Prior to taking up his current position, he was a Wellcome Trust postdoctoral fellow at the University of California, Berkeley, USA, from 1999 to 2000, and then became a lecturer in organic chemistry at the Department of Chemistry, Queen Mary, University of London from 2001 to 2005. Prof. Todd's research group is investigating synthetic methodology, responsive metal complexes, and asymmetric catalysis. He has received awards for his work in open science, most notably his creation of the Open Source Malaria consortium that is trialling a new model of drug discovery.