Sleep and Sleep Disorders

- Section I. Basic Pharmacology: GABAA Receptor Subtypes in Sedation and Hypnosis

- Sleep Hippocampal Theta Rhythm and Sensory Processing

- Monoaminergic Mechanisms in the Regulation of Sleep-Wakefulness: Special Emphasis on Preoptic Noradrenergic System

- REM Sleep Function and Brain Monoamine Regulation: An Application of the Search Activity Concept

-Role of Wakefulness Area in the Brainstem Reticular Formation in Regulating Rapid Eye Movement Sleep

- The Mechanistic Relationship between NREM Sleep and Anesthesia

- Section II. Chronopharmacology: Time-Dependent Psychotropic Drug Effects Hints of Pharmacochronomics, Broader than Circadian Time Structures

- Melatonin Interaction with Bz-Gabaa Receptors: Implications for Sleep Induction

- Melatonin: A Chronobiotic that Not Only Shifts Rhythms

- Melatonin and Human Sleep

- Melatonin Efficacy to Treat Circadian Alterations of Sleep in Alzheimer's Disease

- Pharmacotherapy for Seasonal Affective Disorder

- Use and Discontinuation of Hypnosedative Medications

- Section III. Clinical Pharmacology: Long-Term Use of Sleeping Pills in Chronic Insomnia

- Risks of Chronic Hypnotic Use

- Effects of Psychotropics on Driving Performance

- Diagnosis, Pathophysiology and Treatment of Hypersomnias

- Chronic Disease and Sleep Architecture Pharmacotherapeutic Considerations

- Benzodiazepines for Sedation in Infants and Children

- The Pharmacological Management of Fatigue and Sleepiness in Affective Disorders

- Next-Day Residual Effects of Sleeping Medications on Driving Ability: A Review of the Literature

- Sleep and Pain

- Head Injuries and Sleep

-Psychopharmacological Management of Restless Legs Syndrome and Periodic Limb Movements in Sleep

- A Comparison of Visual Analog Scale and Categorical Ratings in Assessing the Patient's Estimate of Sleep Quality

- The Pharmacostrategy of Treating Sleep Disorders in Parkinsonism

- The Neuropharmacology of

"How far has science gone in understanding the mechanisms of sleep and wakefulness and the pivotal physiologic and pathologic roles of sleep? Sleep and wakefulness constitute major homeostatic systems, whose proper function is crucial to the health and happiness of the individual. Both systems operate at the intersection of the nervous, endocrine, metabolic and immune systems, and their homeostatic mediators include all kinds of molecules, such as neurotransmitters, neuropeptides, hormones and cytokines. This book succeeds in providing, to large extent, the state-of the-art robust knowledge in this important area of science and medicine."George P. Chrousos, M.D., FAAP, MACP, MACE- University of Athens, Athens, Greece- National Institute of Child, Health and Human Development, National Institutes of Health, Bethesda, MD, USA