Smad Signal Transduction

1. Preface: the Smad family; P. ten Dijke and C-H. Heldin

2. Evolution of Smad proteins; S. Newfeld

3. Smad signaling in C. elegans; R. Padgett and G. Paterson

4. Mad signaling in Drosophila; L. Raftery

5. Delineating the TGF-/Smad-induced cytostatic response; F. Liu

6. TGF- /Smad signaling in mesenchymal cell differentiation; R. Derynck

7. Regulation of cell death and survival by Smads; K. Luo

8. TGF-/Smad signaling in epithelial to mesenchymal transition; A. Moustakas

9. Functional analysis of Smads through gene ablation in mice; C. Deng

10. Regulation of Smad activation through endocytic segregation of TGF- receptors; J. Wrana

11. Nucleocytoplasmic shuttling of Smad proteins; C. Hill

12. Structural insights into Smad function and specificity; Y. Shi

13. Regulation of Smad function by phosphorylation; S. Souchelnytskyi

14. Regulation of Smad function through ubiquitination and sumoylation; X.-H. Feng

15. Smad co-activators and co-repressors; K. Miyazono

16. Integration of signaling pathways via Smads and Smad interacting proteins; L. Attisano

17. Interplay between Smad and MAP kinase signaling pathways; A. Mauviel

18. Gene expression signatures of TGF-/Smad-induced responses; E. Bttinger

19. Systems biology approaches to TGF-/Smad signaling; M. Tewari

20. Inhibitory Smads; mechanism of action and role in human diseases; A. Nakao

21. Alterations of Smad signaling in carcinogenesis; S.- J. Kim and J. Letterio

22. TGF- receptor kinase inhibitors for treatment of cancer; J. Yingling

23. TGF- receptor kinase inhibitors for treatment of fibrosis; N. Laping and S. Huet

From the reviews:"This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. ... This is definitely an 'all-in' book for those interested in or working on TGFß receptor signal transduction in general and Smad proteins in particular. ... it is a must for all of us working in the field of TGFß signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 2007)