Sodium Channels, Pain, and Analgesia
(Sprache: Englisch)
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of...
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Klappentext zu „Sodium Channels, Pain, and Analgesia “
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Nav1.3 in neuropathic states is another important theme.
Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Nav1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology.
Inhaltsverzeichnis zu „Sodium Channels, Pain, and Analgesia “
- Voltage-gated sodium channels as therapeutic targets- Structure, function, and classification of sodium channels
- Voltage-gated sodium channels and their role in neuropathy and nerve injury
- Role of voltage-gated sodium channels in human pain states
- Voltage-gated sodium channels and visceral pain
- Dental pain: sodium channels as targets for the development of novel analgesics
- The functional interaction of accessory proteins and the TTX-resistant sodium channel NaV1.8
- TTX-resistant sodium channels in nociceptive nerve endings
- Regulation and modulation of voltage-gated sodium sodium channels
- Sodium channel gating and drug blockade
- Current Opinion and Future Direction.
Bibliographische Angaben
- 2005, 202 Seiten, Maße: 17,5 x 25 cm, Gebunden, Englisch
- Herausgegeben:Coward, Kevin; Baker, Mark D.
- Herausgegeben: Kevin Coward, Mark Baker
- Verlag: Springer
- ISBN-10: 3764370629
- ISBN-13: 9783764370626
- Erscheinungsdatum: 19.07.2005
Sprache:
Englisch
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