Springer Theses / Metallocorroles for Attenuation of Atherosclerosis

Biologically relevant ROS/RNS.- Atherosclerosis.- The pro-atherogenic role of LDL and macrophages.- The anti-atheroginicity of HDL.- Common treatments for atherosclerosis.- Corroles.- Catalytic antioxidants.- Electronic spectra.- Research Goals.- Results.- Interactions of corroles with lipoproteins .- Corrole-lipoproteins binding.- Corrole distribution in serum.- Spectral changes in the presence of lipoprotein components.- The effect of corroles on oxidative-stress-induced lipoprotein damage.- Cu+2-induced oxidation.- Peroxynitrite-induced oxidation.- Lipoprotein function.- Interactions of corroles with macrophages.- Fluorescence-based detection of 1-Ga.- Chemiluminescence-based detection of 1-Fe.- Cellular accumulation of 1-Fe versus iron(III) porphyrins.- The effect of corroles on macrophage atherogenicity.- Effect on oxidative-stress-induced cell death.- Effect on macrophages cholesterol metabolism.-The effect of corroles on the development of atherosclerosis.- Discussion.- Interaction of corroles with lipoproteins.- Corrole distribution in serum.- Mode of 1-Fe binding to lipoproteins.- Materials and Methods.