The Parvoviruses
(Sprache: Englisch)
I. Introduction Parvoviruses belong to the large group of viral agents of which virologists have become aware by chance in many biological materials due to the availabil ity of more sensitive isolation techniques and the extensive use of the electron...
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I. Introduction Parvoviruses belong to the large group of viral agents of which virologists have become aware by chance in many biological materials due to the availabil ity of more sensitive isolation techniques and the extensive use of the electron microscope. In general, many of these viruses lacked the stimulating background of an infectious disease and, therefore, have fallen into oblivion already soon after discovery. In case of parvoviruses, however, interest has been maintained because of the circumstances under which most of them were isolated. A great number of parvoviruses has been recovered from tissues of tumor bearing animals, from cell-free filtrates of tumors, or from stable cell lines of tumor origin. These observations necessarily suggested the newly isolated viral agents of playing an important, yet unknown role in the induction and develop ment of cancer. On the other hand, further parvoviruses were found constantly associated with adenoviruses. It was the experimental analysis of the multiplica tion behaviour which then revealed that the association between parvoviruses and tumors or parvoviruses and adenoviruses originates from the basis of a cer tain genetic defectiveness. For some members of the group this may be overcome by cellular helper effects in rapidly growing tissues, for several others, however, by biochemical events in the simultaneously occurring replication of an adeno virus only. Additional points of view in favour of parvovirus research have arisen from experimental animal studies.
Inhaltsverzeichnis zu „The Parvoviruses “
I. Introduction.- II. Nomenclature and Classification.- III. Properties of Parvoviruses.- A. Hamster-Osteolytic Viruses and Related Isolates.- 1. History.- 2. Morphology.- a) Size.- b) Structure.- 3. Physicochemical Properties.- a) Type and Configuration of Nucleic Acid.- b) Structural Proteins.- c) Buoyant Density and Sedimentation Behaviour.- d) Resistance to Physical and Chemical Agents.- (1) Heat- and pH-Stability.- (2) UV-Irradiation and Ultrasonication.- (3) Organic Solvents.- (4) Enzymes.- (5) Storage.- 4. Antigenic Structure and Serologic Relationship.- a) Hemagglutinin and Hemagglutination.- b) Hemagglutination Inhibition.- c) Cross Neutralization.- d) Complement Fixation and Immunofluorescent Studies.- e) Differences in Antigenic Composition between Various Virus Strains.- 5. Cultivation.- a) Host-Cell Range.- b) Cytopathogenicity.- c) Plaque Formation.- d) Virus Multiplication.- (1) Growth Cycle in Fully Susceptible Cells.- (2) Incomplete Growth Cycle.- (3) Stimulation of Virus Multiplication by "Helper" Viruses.- (4) Dependence of Virus Multiplication on Cell Physiologic State.- (5) Biochemical Characteristics of Virus Synthesis.- 6. Pathogenesis.- a) Natural Hosts.- (1) Rat.- (2) Man.- b) Experimental Hosts.- (1) Hodents.- (2) Monkey.- (3) Man.- c) Vertical Transmission of Viruses.- d) Factors Influencing Pathogenicity.- 7. Clinical and Pathological Features in Infected Rodents.- a) Natural Infection.- b) Experimental Infection.- (1) Acute, Lethal Disease in Newborn Animals.- (2) The Osteolytic Syndrome (Malformation of Teeth and Bones, Dwarfism and Mongolism).- (3) Cerebellar Ataxia.- (4) Hemorrhagic Encephalitis.- 8. Immunity.- a) Active Immunity.- b) Passive Immunity.- 9. Epizootiology.- B. The Minute Virus of Mice (MVM).- 1. History.- 2. Morphology.- 3. Physicochemical Characteristics.- a) Configuration of Nucleic Acid.- b) Buoyant Density and Sedimentation Behaviour.- 4. Antigenic Structure and Serologic Properties.- 5. Growth Characteristics.- a)
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Cultivation.- b) Virus Multiplication.- 6. Pathogenesis.- a) Natural Host(s).- b) Experimental Hosts.- c) Transmission.- C. Porcine Parvovirus (PPV).- 1. History.- 2. Morphology.- 3. Physicochemical Characteristics.- a) Type of Nucleic Acid.- b) Buoyant Density.- c) Resistance to Physical and Chemical Agents.- (1) Heat.- (2) pH-Stability.- (3) Organic Solvents.- (4) Trypsin.- (5) Storage at Low Temperature.- 4. Antigenic Structure.- 5. Cultivation.- a) Host-Cell Range.- b) Cytopathogenicity and Virus Multiplication.- 6. Pathogenicity.- 7. Immunity.- D. Feline Panleukopenia Virus (FPV).- 1. History.- 2. Morphology.- 3. Physicochemical Characteristics.- a) Viral Nucleic Acid and Proteins.- b) Buoyant Density.- c) Resistance to Physical and Chemical Agents.- 4. Antigenic Structure and Serological Properties.- 5. Cultivation.- a) Host-Cell Range.- b) Cytopathogenicity.- c) Virus Multiplication.- 6. Pathogenesis.- a) Natural Hosts.- b) Experimental Hosts.- 7. Clinico-Pathological Features.- a) Classical Disease.- (1) Felines.- (2) Mink.- b) Ataxia.- 8. Immunity.- 9. Epizootiology.- E. Bovine Parvovirus (BPV).- 1. History.- 2. Size of the Particle and Physicochemical Properties.- 3. Antigenicity.- 4. Cultivation.- 5. Pathogenicity.- F. Minute Virus of Canines (MVC).- G. Parvoviruses Isolated from Permanent Human Cell Lines.- 1. History.- 2. Morphology.- 3. Physicochemical Characteristics.- a) Type and Configuration of Nucleic Acid.- b) Structural Proteins.- c) Buoyant Density.- d) Sedimentation Coefficients.- e) Resistance to Physical and Chemical Agents.- (1) Heat and pH.- (2) Organic Solvents and Na-Deoxycholate.- (3) Enzymes.- (4) Storage.- 4. Antigenicity and Serologic Properties.- a) Characteristics of the Hemagglutinin.- b) Hemagglutination Pattern.- c) Hemadsorption.- d) Serologic Properties.- 5. Cultural Characteristics.- a) Parvovirus-Contaminated Cell Lines.- (1) Origin of Isolates.- (2) Cultural Behaviour.- b) Experimentally Infected Cell Cultures.- (1) Host-Cell Range.- (2) Virus Multiplication and Cytopathogenicity.- (3) Virus Synthesis.- 6. Pathogenicity.- IV. General Survey.- V. Addendum.- References.
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Bibliographische Angaben
- Autor: Günter Siegl
- 2012, Softcover reprint of the original 1st ed. 1976, IV, 112 Seiten, Maße: 17 x 24,4 cm, Kartoniert (TB), Englisch
- Verlag: Springer
- ISBN-10: 3709184320
- ISBN-13: 9783709184325
- Erscheinungsdatum: 19.01.2012
Sprache:
Englisch
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