Topical and Transdermal Drug Delivery
Principles and Practice
(Sprache: Englisch)
Practical drug development approaches presented by leading experts
Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and...
Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and...
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Practical drug development approaches presented by leading expertsDesigned to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development.
Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts:
* Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment.
* Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.
Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.
With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of
Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development.
Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts:
- Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment.
- Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field.
This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.
Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.
With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.oaches, covering such issues as skin permeation, enhancement, and assessment.
- Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field.
This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.
Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.
With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and
Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts:
- Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment.
- Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field.
This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.
Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.
With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.oaches, covering such issues as skin permeation, enhancement, and assessment.
- Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field.
This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.
Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.
With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and
Inhaltsverzeichnis zu „Topical and Transdermal Drug Delivery “
- Preface- Contributors
Part 1. Current science, skin permeation and enhancement approaches
Chapter 1. Skin structure, function and permeation (Heather A. E. Benson)
Chapter 2. Passive skin permeation enhancement (Majella E. Lane, Paulo Santos, Adam C. Watkinson, Jonathan Hadgraft)
Chapter 3. Electrical and physical methods of skin penetration enhancement (Jeffrey E. Grice, Tarl Prow, Mark Kendall, Michael S. Roberts)
Chapter 4. Clinical applications of transdermal iontophoresis (D. R. Kalaria, S. Dubey and Y. N. Kalia)
Chapter 5. In vitro skin permeation methodology (Barrie Finnin, Kenneth A. Walters and Thomas J. Franz)
Chapter 6. Skin permeation assessment: tape stripping (Sandra Wiedersberg and Sara Nicoli)
Chapter 7. Skin permeation assessment: microdialysis (R. Holmgaard, JB Nielsen and E. Benfeldt)
Chapter 8. Skin permeation assessment: spectroscopic methods (Jon Hadgraft, Majella Lane)
Chapter 9. Skin permeation assessment in man: in vitro - in vivo correlation (Paul A. Lehman, Sam G. Raney, Thomas J. Franz)
Chapter 10. Risk assessment (Jon R. Heylings)
Part 2. Topical and Transdermal Product Development
Chapter 11. An Overview of Product Development From Concept To Approval (Adam C. Watkinson)
Chapter 12. Regulatory Aspects of Drug Development for Dermal Products (William K. Sietsema)
Chapter 13. Toxicological and preclinical considerations for novel excipients and NCEs (Andrew Makin, Jen Thing Mortensen)
Chapter 14. Topical product formulation development (Marc B. Brown, Robert Turner and Sian T. Lim)
Chapter 15. Transdermal product formulation development (Kenneth J. Miller)
Chapter 16. Sensitivity and irritation testing (Belum Viswanath Reddy, Geetanjali Sethi, Howard I. Maibach)
Chapter 17. New Product Development for Transdermal Drug Delivery: Understanding the Market Opportunity (Hugh Alsop)
Chapter 18. Transdermal and topical drug delivery today (Adam C. Watkinson)
Chapter 19. Current
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and future trends: Skin diseases and treatment (Simon G. Danby and Michael J. Cork)Chapter 11. An Overview of Product Development From Concept To Approval (Adam C. Watkinson)
Chapter 12. Regulatory Aspects of Drug Development for Dermal Products (William K. Sietsema)
Chapter 13. Toxicological and preclinical considerations for novel excipients and NCEs (Andrew Makin, Jen Thing Mortensen)
Chapter 14. Topical product formulation development (Marc B. Brown, Robert Turner and Sian T. Lim)
Chapter 15. Transdermal product formulation development (Kenneth J. Miller)
Chapter 16. Sensitivity and irritation testing (Belum Viswanath Reddy, Geetanjali Sethi, Howard I. Maibach)
Chapter 12. Regulatory Aspects of Drug Development for Dermal Products (William K. Sietsema)
Chapter 13. Toxicological and preclinical considerations for novel excipients and NCEs (Andrew Makin, Jen Thing Mortensen)
Chapter 14. Topical product formulation development (Marc B. Brown, Robert Turner and Sian T. Lim)
Chapter 15. Transdermal product formulation development (Kenneth J. Miller)
Chapter 16. Sensitivity and irritation testing (Belum Viswanath Reddy, Geetanjali Sethi, Howard I. Maibach)
... weniger
Autoren-Porträt von Heather A. E. Benson, Adam C. Watkinson
Heather A. E. Benson, PhD, is an Associate Professor in the School of Pharmacy at Curtin University, Australia, where she leads the Skin Delivery Research Group. Internationally recognized for her research in skin biology and drug/peptide delivery, Dr. Benson has published more than 100 peer-reviewed publications on the topic of drug delivery.Adam C. Watkinson, MBA, PhD, has worked in topical and transdermal drug delivery for twenty-three years and played key roles in the development of Axiron (transdermal testosterone) and Sancuso (transdermal granisetron) while at Acrux and ProStrakan, respectively. He has published extensively on his research, is the author of several patents, and holds an Honorary Chair at the School of Pharmacy at the University of London. He runs Storith Consulting, a firm offering advice in the areas of drug development and topical and transdermal drug delivery.
Bibliographische Angaben
- Autoren: Heather A. E. Benson , Adam C. Watkinson
- 2012, 1. Auflage, 440 Seiten, Maße: 16,1 x 24 cm, Gebunden, Englisch
- Verlag: Wiley & Sons
- ISBN-10: 0470450290
- ISBN-13: 9780470450291
- Erscheinungsdatum: 06.02.2012
Sprache:
Englisch
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