Tumor Biomarker Discovery: Methods and Protocols
(Sprache: Englisch)
Biomarkers are molecular indicators of a biological status and, as biochemical species, can be interrogated to evaluate disease status and therapeutic interventions. Biomarkers may be detectable in the blood, other body fluids, or tissues. The expectation...
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Klappentext zu „Tumor Biomarker Discovery: Methods and Protocols “
Biomarkers are molecular indicators of a biological status and, as biochemical species, can be interrogated to evaluate disease status and therapeutic interventions. Biomarkers may be detectable in the blood, other body fluids, or tissues. The expectation is that the level of an informative biomarker is related to the specific type of disease present in the body. Hence, disease-relevant biomarkers can be used to measure the presence, progress, or intensity of disease. Through a variety of mechanisms, cancer cells provide the biomarker material for their own detection. Tumor biomarkers include cancer-specific mutations or changes in gene expression, both of which can result in aberrant protein expression. These variant or abundant proteins can be detectable in the circulation as the free proteins or as novel autoantibodies to those proteins, the latter indicating that the immune system can provide an exquisitely sensitive sensor of disease. Because cancer cells shed DNA in the circu- tion, an event rarely seen in healthy individuals, tumor-specific genetic changes, such as promoter methylation or gene mutations, are detectable in DNA prepared from plasma or other body fluids. Cancer-related biochemical changes often effect measurable me- bolic variations within a cell or organism. In addition, these biochemical changes result in posttranslational modification of proteins via glycosylation or phosphorylation providing a plethora of opportunity for biomarker discovery.
Inhaltsverzeichnis zu „Tumor Biomarker Discovery: Methods and Protocols “
1. Identification of Tumor-Associated Antigens (TAAs) as Diagnostic and Predictive Biomarkers in CancerJian-Ying Zhang, Kok Sun Looi, and Eng M. Tan2. Autoantibodies against Cancer AntigensSacha Gnjatic, Lloyd J. Old, and Yao-Tseng Chen3. Discovery of Antibody Biomarkers Using Protein Microarrays of Tumor Antigens Cloned in High-ThroughputMadhumita Chatterjee, Jerzy Wojciechowski, and Michael A. Tainsky4. Analysis of Glycans on Serum Proteins Using Antibody MicroarraysSongming Chen and Brian B. Haab5. Glycoproteomic Analysis by Two Dimensional ElectrophoresisMary Ann Comunale and Anand Mehta6. All-Liquid Separations, Protein Microarrays and Mass Spectrometry to Interrogate Serum Proteomes: An Application to Serum GlycoproteomicsTasneem H. Patwa, Yinghua Qiu, Jia Zhao, Diane M. Simeone, and David M. Lubman7. Reverse Phase Protein Microarrays for Theranostics and Patient Tailored TherapyVirginia Espina, Lance A. Liotta, and Emanuel F. Petricoin III8. Serum Proteomics Using Mass SpectrometryBrian L. Hood, David E. Malehorn, Thomas P. Conrads, and William L. Bigbee9. Hormones as Biomarkers: Practical Guide to Utilizing Luminex Technolgies for Biomarker ResearchFaina Linkov, Zoya Yurkovetsky, and Anna Lokshin10. High-Throughput Analysis of Serum Antigens Using Sandwich ELISAs on MicroarraysShannon L. Servoss, Rachel Gonzalez, Susan Varnum, and Richard C. Zangar11. Tissue Microarrays as a Tool in the Discovery and Validation of Tumor MarkersStephen M. Hewitt12. Quantitative, Fluorescence-Based In-Situ Assessment of Protein ExpressionChristopher B. Moeder, Jennifer M. Giltnane, Sharon Pozner Moulis, and David L. Rimm13. Tumor Marker Discovery by Expression Profiling RNA from Formalin Fixed Paraffin Embedded TissuesMaureen T. Cronin, Debjani Dutta, Mylan Pho, Anhthu Nugyen, Jennie Jeong, and Mei-Lan Liu14. High-Throughput Mutation Screening Using a Single Amplification ConditionLijia Shi and John E. Landers15. DNA Sequencing of Cancer-Related Genes for Biomarker
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DiscoveryLisa M. Farwell and Victoria A. Joshi16. Analysis of Loss of Heterozygosity in Circulating DNATakeshi Nakamura, Eiji Sunami, and Dave S. B. Hoon17. PharmacogenomicsShilong Zhong and Marjorie Romkes18. Study Designs in Genetic EpidemiologyMichele L. Cote19. Developing Classifiers for the Detection of Cancer Using Multi-AnalytesAdi Laurentiu Tarca, Sorin Draghici, and Roberto Romero20. Metabolomics of CancerNatalie J. Serkova and Kristine Glunde21. MRI and MRS of Human Brain TumorsBob L. Hou and Jiani Hu22. Magnetic Resonance Spectroscopy of Living TissuesNatalie J. Serkova, Kendra M. Hasebroock, and Susan L. Kraft
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Bibliographische Angaben
- 2009, 332 Seiten, Maße: 20 x 27 cm, Gebunden, Englisch
- Herausgegeben: Michael A. Tainsky
- Verlag: Humana Press
- ISBN-10: 1603278109
- ISBN-13: 9781603278102
Sprache:
Englisch
Rezension zu „Tumor Biomarker Discovery: Methods and Protocols “
From the reviews:"This well-illustrated book is an excellent resource on nucleic acid and protein-based technologies and metabolic profiling by analytic means or mass spectroscopy as well as for study designs for tumor biomarker discovery and validation. The audience includes both researchers interested in the identification and development of new tumor biomarkers and clinicians who need to be familiar with these new technologies in order to ... treat cancer patients. In addition to researchers and clinicians, students interested in tumor biomarkers will find this book extremely useful." (Omer Iqbal, Doody's Review Service, January, 2010)
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