Amino Acids, Peptides and Proteins in Organic Chemistry / Amino Acids, Peptides and Proteins in Organic Chemistry Bd.4 (PDF)

PROTECTION REACTIONS General Considerations Alpha-Amino Protection (Nalpha-Protection) Carboxy Protection Side Chain Protection Photocleavable Protections Conclusion Experimental Section THE HUISGEN CYCLOADDITION IN PEPTIDOMIMETIC CHEMISTRY Introduction The Huisgen [2+3] Cycloaddition Between Azides and Acetylenes Mechanistic Consideration for the Cu-Huisgen and Ru-Huisgen Cycloaddition Building Blocks for the Synthesis of Triazole Modified Peptidomimetics Cyclic Triazole Peptidomimetics Acylic Triazole Peptidomimetics Useful Experimental Procedures RECENT ADVANCES IN BETA-STRAND MIMETICS Introduction Macrocyclic Peptidomimetics Acyclic Compounds Aliphatic and Aromatic Carbocycles Ligands Containing One Ring or Multiple Rings with One Heteroatom (O, S) Ligands Containing One Ring with Two Heteroatoms (N,N) Ligands Containing One Ring with Two Heteroatoms (N,S) or Three Heteroatoms (N,N,S or N,N,N) Ligands Containing Two Rings with One Heteroatom (N or O) Ligands Containing Two Rings with Two or Three Heteroatoms (N,N or N,S or N,N,N) Concluding Remarks MEDICINAL CHEMISTRY OF ALPHA-AMINO ACIDS Introduction Glutamic Acid Conformational Restriction Bioisosterism Structure-Activity-Studies Conclusion MEDICINAL CHEMISTRY OF ALICYCLIC BETA-AMINO ACIDS Introduction Five-Membered Alicyclic Beta-Amino Acids Six-Membered Alicyclic Beta-Amino Acids MEDICINAL CHEMISTRY OF ALPHA-HYDROXY-BETA-AMINO ACIDS Introduction Alpha-Hydroxy-Beta-Amino Acids Antibacterial Agents Inhibitors of Aminopeptidases Aspartyl Proteases Inhibitors Paclitaxel and its Derivatives PEPTIDE DRUGS Lights and Shades of Peptide and Protein Drugs Peptide Drugs Available on the Market Approved Peptides in Oncology Antimicrobial Peptides Perspectives ORAL BIOAVAILABILITY OF PEPTIDE AND PEPTIDOMIMETIC DRUGS Introduction Fundamental Considerations of Intestinal Absorption Barriers Limiting Oral Peptide/Peptidomimetic Drugs Bioavailability Strategies to Improve Peptide-Based Drugs Oral Bioavailability Conclusions

Andrew Hughes is a Reader and Head of the Department of Chemistry, La Trobe University, Melbourne, Australia. He obtained his degrees from the University of Western Australia. Post-doctoral appointments at the University of Cambridge starting 1989 included 3 years working with Professor Andrew Holmes before joining Professor Steven Leys group in 1993. While at Cambridge he was appointed the Shell Research Fellow at Robinson College.

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