Applications of Microdialysis in Pharmaceutical Science (PDF)

Discover new and emerging applications for microdialysis in drug
evaluation

Microdialysis is a highly valuable sampling tool that can be
used in vivo to measure free, unbound analyte concentrations
located in interstitial and extracellular spaces. This book
explores the full range of clinical applications for microdialysis,
focusing on its use in different organ and tissue systems for
pharmacokinetic and pharmacodynamic studies. Readers gain a full
understanding of the underlying science of microdialysis, current
techniques and practices, as well as its many applications in
pharmaceutical research.

Applications of Microdialysis in Pharmaceutical Science starts
with an introduction to basic principles and then covers analytical
considerations, pharmacodynamic and pharmacokinetic studies,
clinical aspects, and special applications. Topics include:

* Role of microdialysis in drug development, including crucial
sampling considerations and applications for nervous system
diseases

* Continuous measurement of glucose concentrations in
diabetics

* Applications for clinical evaluation and basic research on organ
systems, including monitoring exogenous and endogenous compounds in
the lungs

* Pharmacokinetic and pharmacodynamic evaluation of anticancer
drugs

* Comparison of microdialysis with imaging approaches to evaluate
in vivo drug distribution

* Special applications of microdialysis in studies of cell culture
assays, drug-drug interactions, and environmental monitoring

Throughout the book, readers will find simple models that
clarify complex concepts and easy-to-follow examples that guide
them through key applications in pharmaceutical research. In short,
this book enables pharmaceutical researchers to take full advantage
of microdialysis techniques for the preclinical and clinical
evaluation of drugs and much more.