Levodopa-Induced Dyskinesia in Parkinson's Disease (PDF)
Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors...
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This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from 'bench to bedside'.
Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; ongoing RCTs in LID; and evidence-based medicine reviews of treatment options.
Levodopa-Induced Dyskinesia in Parkinson's Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees; and graduate and post-graduate students.¿
Jonathan Brotchie, PhD, is Senior Scientist at the Toronto Western Hospital, University Health Network (UHN). At UHN, he leads a research programme focused on the discovery and validation of novel therapeutic targets for Parkinson's disease and the development of therapeutics based upon those targets. The particular expertise of his group and collaborators at UHN lies in transitioning development programmes from pre-clinical efficacy to Phase II proof-of-concept. Dr Brotchie is also Founder and a Director of Atuka Ltd, a CRO specialising in the provision of support for developing therapies for neurodegenerative disorders.
- 2014, 2014, 368 Seiten, Englisch
- Herausgegeben: Susan H. Fox, Jonathan M. Brotchie
- Verlag: Springer-Verlag GmbH
- ISBN-10: 1447165039
- ISBN-13: 9781447165033
- Erscheinungsdatum: 08.10.2014
Abhängig von Bildschirmgröße und eingestellter Schriftgröße kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: PDF
- Größe: 5.82 MB
- Ohne Kopierschutz
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