Matrix Proteases in Health and Disease (PDF)

Preface Introduction MATRIX PROTEASES AND THE DEGRADOME Introduction Bioinformatic Tools for the Analysis of Complex Degradomes Evolution of Mammalian Degradomes Human Diseases of Proteolysis Matrix Proteases and Their Inhibitors THE PLASMINOGEN ACTIVATION SYSTEM IN NORMAL TISSUE REMODELING Introduction Biochemical and Enzymological Fundamentals Biological Roles of the Plasminogen Activation System Tissue Remodeling Processes Conclusions PHYSIOLOGICAL FUNCTIONS OF MEMBRANE-TYPE METALLOPROTEASES Introduction Historical Perspective Activation of the Activator Potential Roles of MT-MMPs and Discovery of a Human MMP Mutation MT-MMP Function? Physiological Roles of MT1-MMP in the Mouse MT1-MMP Function in Lung Development MT1-MMP Is Required for Root Formation and Molar Eruption Identification of Cooperative Pathways for Collagen Metabolism MT-MMP Activity in the Hematopoietic Environment Physiological Role of MT2-MMP MT-Type MMPs Work in Concert to Execute Matrix Remodeling 67MT4-MMP - an MT-MMP with Elusive Function MT5-MMP Modulates Neuronal Growth and Nociception Summary and Concluding Remarks BONE REMODELING: CATHEPSIN K IN COLLAGEN TURNOVER Introduction Proteolytic Machinery of Bone Resorption and Cathepsin K Specificity and Mechanism of Collagenase Activity of Cathepsin K Role of Glycosaminoglycans in Bone Diseases Development of Specific Cathepsin K Inhibitors and Clinical Trials Off-Target and Off-Site Inhibition Conclusion TYPE-II TRANSMEMBRANE SERINE PROTEASES: PHYSIOLOGICAL FUNCTIONS AND PATHOLOGICAL ASPECTS Introduction Functional/Structural Properties of TTSPs Physiology and Pathobiology PLASMINOGEN ACTIVATORS IN ISCHEMIC STROKE Introduction Rationale for Thrombolysis after Stroke Preclinical Studies The Association of Endogenous tPA with Excitotoxic and Ischemic Brain Injury Mechanistic Studies of tPA in Excitotoxic and Ischemic Brain Injury tPA and the Blood-Brain Barrier-PDGF-CC Summary BACTERIAL ABUSE OF MAMMALIAN EXTRACELLULAR PROTEASES DURING

Niels Behrendt is a research group leader at the Finsen Laboratory at the Rigshospitalet (Copenhagen University Hospital), Denmark. He obtained his Ph.D. in 1989 and his D.Sc. degree from Copenhagen University in 2004. The main focus of his work is in protease-dependent tissue remodeling, the interplay of these processes with other cellular functions and their role in cancer invasion.

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