Redox-Active Therapeutics / Oxidative Stress in Applied Basic Research and Clinical Practice (PDF)
essential volume comprehensively discusses redox-active therapeutics, focusing
particularly on their molecular design, mechanistic, pharmacological and
medicinal aspects. The first section of the book describes the basic
aspects of the chemistry...
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This
essential volume comprehensively discusses redox-active therapeutics, focusing
particularly on their molecular design, mechanistic, pharmacological and
medicinal aspects. The first section of the book describes the basic
aspects of the chemistry and biology of redox-active drugs and includes a brief
overview of the redox-based pathways involved in cancer (such as the role of
mitochondria, hydrogen peroxide and endogenous antioxidative defenses) and the
medical aspects of redox-active drugs, assuming little in the way of prior
knowledge. The second section encompasses several major classes of redox-active
experimental therapeutics, which include porphyrins, salens, nitrones, and
other metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single
compounds or formulations with nanomaterials and quantum dots. Subsequent
sections and chapters describe more specialized aspects of redox-active
therapeutics in clinical disorders, such as cancer, cardiovascular diseases,
diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiation
injury and radioprotection (such as of brain, lungs, head and neck and erectile
function) and neglected diseases (e.g., leishmaniasis). Numerous illustrations, tables
and figures enhance and complement the text; extensive references to relevant
literature are also included.
Redox-Active Therapeutics is an invaluable addition
to Springer's Oxidative Stress in Applied Basic Research and Clinical
Practice series. It is essential reading for researchers, clinicians
and graduate students interested in understanding and exploring the
Redoxome-the organism redox network-as an emerging frontier in drug design,
redox biology and medicine.
PhD
Ines Batinic-Haberle is a Professor of Radiation
Oncology at the Department of Radiation Oncology, Duke University School of
Medicine. She received her B.Sc. in Food Chemistry, M.Sc. degree in Analytical
Chemistry, and her Ph.D. degree in Bioinorganic Chemistry from the School of
Pharmacy and Biochemistry, University of Zagreb, Croatia. She completed her
postdoctoral education at the Department of Chemistry, Duke University. She then
moved to the Department of Biochemistry at Duke University School of Medicine,
where she was trained by Irwin Fridovich, the Father of the field of Free Radicals in Biology and Medicine. She
spent 10 years in Fridovich's Lab where she acquired the basis of her expertise
in Oxidative Stress and Redox-Active Therapeutics and launched
the design of powerful Mn porphyrin-based SOD mimics. She established the structure-activity
relationship for Mn porphyrin-based SOD mimics, which she subsequently extended
to all classes of SOD mimics. She holds a number of compositional and methods
of use patents on metalloporphyrins; her lead compounds are either already in
or entering Clinical Trials in 2016. She authored more than 190 manuscripts,
several book chapters, has served as Guest/Invited Editor and reviewer of
various prestigious journals and granting agencies both nationally and internationally.
For the last 6 years she has served as a Society
for Redox Biology and Medicine (SFRBM) Officer and is a founding member of
the Society of Porphyrins and
Phthalocyanines. She was recently awarded the SFRBM Excellence in Mentoring
Award. She has organized numerous Symposia nationally and internationally and
gave lectures at numerous Universities in the USA and abroad. She has
established numerous collaborations with research groups in USA and
internationally and worked actively in advancing metalloporphyrins towards
clinic.
JULIO S. REBOUCAS, PhD
Julio
S.
Brazil), Adjunct Head of the UFPB Chemistry Graduate Programs, and Fellow of
the Brazilian National Research Council (CNPq). He received his Chemical
Engineering B.Sc. and Chemistry M.Sc. degrees from Universidade Federal de Minas
Gerais (Brazil) and his Chemistry Ph.D. degree from the University of British
Columbia (Canada). He joined the Batinic-Haberle and Spasojevic Laboratories at
Duke University (USA) in 2006, where he completed his postdoctoral training in oxidative
stress and porphyrin-based redox-active therapeutics, before moving to UFPB in
2009 to establish an accredited porphyrin research group. His research spans
the fields of medicinal and inorganic chemistry, with emphasis on
porphyrin-based biomimetic systems. He has co-authored 52 manuscripts, two book
chapters, and has one patent application. He is a founding member of the Society of Porphyrins and Phthalocyanines
and currently serves as the elected Inorganic Chemistry Division secretary of
the Brazilian Chemical Society. Among
his honors and awards is receiving the Young Investigator Award by the Society for Redox Biology and Medicine. He
has collaborated with various groups within Brazil and abroad on porphyrin
chemistry and medicine.
IVAN SPASOJEVIC, PhD
Ivan Spasojevic
is an Assistant Professor of Medicine at the Department of Medicine, Division
of Oncology. He is also a Director of the PK/PD Core Lab of Duke Cancer
Institute Pharmaceutical Research Shared Resource, an NCI-supported
state-of-the-art bioanalytical facility providing study design and modeling
expertise in pharmacokinetics/pharmacodynamics (PK/PD) and performing analysis
of drugs and their metabolites, oxidative stress markers and other small
biomolecules in general. His Lab has provided the invaluable support in the
development of Mn porphyrins towards Clinical Trials. Ivan earned his B.Sc.
degree in Chemical Engineering from the School of Chemical Engineering, Zagreb,
Croatia and his Ph.D. Degree in Bioinorganic Chemistry from the Department of
Chemistry, Duke University. He completed his postdoctoral training with Irwin
Fridovich in the field of Oxidative stress and Free Radicals in
Biology and Medicine and started his work on the design of Mn
porphyrin-based SOD mimics. He has co-authored 126 manuscripts including
several Book Chapters, has several compositional and method of use patents and
patent applications. He has served as Guest/Invited Editor and reviewer of
various prestigious journals and was invited speaker/organized symposia at National
and International Meetings. He is a founding member of the Society of
Porphyrins and Phthalocyanines. He has collaborated with numerous groups in
and outside of USA in the field of drug development and pharmacokinetics.
- 2016, 1st ed. 2016, 694 Seiten, Englisch
- Herausgegeben: Ines Batinic-Haberle, Júlio S. Rebouças, Ivan Spasojevic
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319307053
- ISBN-13: 9783319307053
- Erscheinungsdatum: 13.10.2016
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