Targeting Notch in Cancer (PDF)

Ergon Professor of Medicine. He held that post until his move to LSUHSC in 2014. His current work focuses on the role of Notch1 in regulating mitochondrial metabolism in triple-negative breast cancer, the role of Notch4 in endocrine-resistant estrogen-receptor positive breast cancer, the role of Notch1 in anti-tumor CD8 T cell responses and the targeting of Notch ligand Jagged in cancer immunotherapy. Additionally, Dr. Miele's group is exploring novel approaches to selective targeting of Notch in breast cancer. Dr. Miele has authored over 220 peer-reviewed publications in biomedical journals to date. He regularly chairs or serves on scientific grant review panels for NIH, NCI, NCATS, the DOD and research funding agencies from Canada, the UK, Spain, Italy, The Netherlands and Singapore. He serves as Editor or Associate Editor of a number of biomedical journals, and has consulted for several pharmaceutical and biotechnology companies regarding Notch-targeting strategies.




Dr. Artavanis-Tsakonas is a molecular biologist and developmental geneticist. He did his undergraduate studies at the ETH in Zurich and earned a MSc in Chemistry and has a PhD from Cambridge University, for work carried out at the MRC Laboratory of Molecular Biology. After his postdoctoral work at the Biozentrum in Basel and at Stanford University, he joined the Yale faculty in 1982. He rose to Professor at the Department of Biology and Professor at the Department of Cell Biology at the Yale School of Medicine and also served as the Director of the Biological Sciences Division at Yale. He was a Howard Hughes Medical Institute Investigator from 1987 to 1998 when he left for Harvard. In 1999 was elected Professor at the Collège de France, in Paris holding the Chair of Biology and Genetics of Development until 2012 when he became Professeur honoraire. He is the Founding Director of the Department of Genetics and Developmental Biology at Institute Curie, Paris, 2007-2009.







In 1998 he joined the Cell Biology Department at the Harvard Medical School where he is now Professor Emeritus and from1999-2007 was also the Isselbacher-Schwartz Professor, Massachusetts General Hospital Cancer Center. From 2012 to March 2017 he was the Chief Scientific Officer for Biogen. He is the founding Director of the Developmental and Regenerative Biology Program at Harvard Medical School.





His laboratory has been, for many years, utilizing model organisms to define critical targets and pathways important in development and disease and pioneered the use of genetic and molecular approaches to define and analyze the Notch signaling pathway. Currently, at his Harvard Medical School laboratory, he is using genetic tools to dissect neurodegeneration pathways related to human disease and is completing work defining the Drosophila Proteome.









He is a fellow of the American Academy of Arts and Sciences, an associate member of EMBO and a corresponding member of the Athens Academy. In addition to his academic credentials, Dr. Artavanis-Tsakonas is a co-founder of Exelixis, Cellzome, and Anadys, and is the president and co-founder of the philanthropic organization Fondation Santé.