The Science and Practice of Lithium Therapy (PDF)
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This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action. The book is divided into two parts, on the science of lithium and the practice of lithium therapy. The former covers aspects such as the properties of the lithium ion, pharmacokinetics and pharmacodynamics, impact on neurotransmission, and gene expression modulation. The section on practice includes discussion of variability in response to lithium, use of lithium in the treatment of bipolar disorders, its value in suicide prevention, administration during pregnancy and in the pediatric age group, and side effects.
Lithium is arguably the only true mood stabilizer, and its multifaceted effects across many clinical domains have given rise to a resurgence of interest in recent years, fuelled by both researchers and clinicians. Nevertheless, its use remains constrained by exaggerated concerns about potential side-effects. In reality, lithium is a simple molecule that is relatively straightforward to administer and monitor and has potentially profound benefits at a fraction of the cost of contemporary agents. This book dispels the many myths and concerns that surround its use and will be of interest for clinicians and researchers worldwide.
Marc Masson, MD, is a Psychiatrist and the Medical Director of the Nightingale Hospital Paris-Clinique du Château de Garches and Consultant, Service Hospitalo-Universitaire, Centre Hospitalier Sainte-Anne, Paris, France. After graduating from Bordeaux University in France, he worked as a psychiatrist at Assistance Publique Hôpitaux de Paris (APHP). He has served as
Frank Bellivier MD, PhD is Professor of Adult Psychiatry at University Denis Diderot in Paris, and Head of the Departments of Psychiatry and Addiction at Saint-Louis - Lariboisière - F. Widal hospitals in Paris. He is also director of a research team on neuropsychopharmacology of bipolar disorders and addictions at the Institut National de la Santé et de la Recherche Médicale (INSERM UMRS_1144, www.umrs1144.com). He received his medical degree at the University of Paris (René Descartes). There, he also completed his residency training and a PhD in Neurosciences, before undertaking a research fellowship at Pitié-Salpêtrière Hospital, Paris. He has led several large clinical programmes for patients with mood disorders, including the Early Onset Bipolar Disorders Program, funded by INSERM and the Assistance Publique Hôpitaux de Paris (APHP). Since 2007, he has led collaborative research programmes on genetic vulnerability factors in bipolar disorders and is currently conducting a prospective follow-up study on cognitive deficits and relapse risk factors in bipolar disorder. He is the recipient of several research prizes including the University of Paris 12 Research Prize (2000), the Jules Baillarger Prize (2002) and the NARSAD Independent Investigator Award (2004). His ongoing research program on biomarkers of lithium response is funded by the National Research Agency (ANR générique 2014), the Sorbonne Paris Cité University, the French Ministry of Research (PHRC) and the FondaMental/Dassault Fondations Research Prize (2013). He has published over 200 papers and is the author of many books and book chapters.
- 2016, 1st ed. 2017, 342 Seiten, Englisch
- Herausgegeben: Gin S. Malhi, Marc Masson, Frank Bellivier
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319459236
- ISBN-13: 9783319459233
- Erscheinungsdatum: 24.11.2016
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- Größe: 7.03 MB
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“This book is a comprehensive review of lithium, a simple but powerful molecule with profound benefits to patients. … It will be of interest for clinicians and researchers worldwide as well as to patients and their families- the recipients of lithium therapy.” (Branka Aukst Margetić, Alcoholism and Psychiatry Research, Vol. 53 (1), 2017)
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