Tumor Liquid Biopsies / Recent Results in Cancer Research Bd.215 (PDF)

Florence Schaffner obtained her PhD in Cell Biology and Biochemistry in Freiburg-im-Breisgau (Germany), in Prof. Hellmut Augustin's angiogenesis and tumor biology lab. There, she studied in depth the role of the interaction between the receptor EphB4 and its ligand ephrinB2 during tumor angiogenesis and metastatic processes and in particular tumor cell seeding at the site of metastasis. She then took up a postdoctoral research position at Scripps Research Institute in California, under Prof. Wolfram Ruf, where she investigated the role of coagulation proteins such as tissue factor and the protease-activated receptor in tumor angiogenesis, metastasis, and cancer stem cell biology. She continued her work on cancer stem cells in France, in Dr. Dontenwill's lab in Strasbourg. She now works at the Cancéropôle Grand-East, where she is developing new and innovative research axes in relation to translational medicine.

Jean-Louis Merlin obtained his PharmD in Lille (France) and his PhDand Research Direction degree in Nancy (France), while working in Prof. Vigneron's lab (Faculty of Pharmacy) on innovative anticancer drug targeting in liposomes and molecular mechanisms of drug resistance in preclinical models. While head of the research lab at the Alexis Vautrin Cancer Center (now the Institut de Cancérologie de Lorraine) in Nancy, he became Professor of Cellular Oncology at the Faculty of Pharmacy. There he set up the tumor biology unit to implement the analysis of molecular tumor genetic markers in the clinical management of cancer patients. Professor Merlin coordinates the Advanced Diagnostic and Translational Research project of the CNRS research unit (UMR 7039) and the Translational Research axis at Cancéropôle Grand-East. He is also coordinating several clinical trials aiming at the validation of circulating tumor DNA as an alternative to tumor DNA for molecular diagnosis and follow-up of patients with colorectal and breast cancer, and