A History of Experimental Virology

1 2000 Years Preceded the Emergence of Experimental Virology.- 1.1 Antiquity and the Origin of the Plague.- 1.2 The Cornerstones of Generatio Spontanea Begin to Quake.- 1.3 The Germ Theory is Born and Proven.- 1.4 The Germ Theory Crystallizes into the Germ Doctrine.- 1.5 The Theoretical and Experimental Basis of the Germ Doctrine at the End of the 19th Century.- 2 Microscopes and Culture Media Fail.- 2.1 The Virus and Koch's Postulates.- 2.2 A New Type of Pathogenic Agent?.- 3 Are Filterable Viruses Miniscule Bacteria?.- 3.1 The Use of Physical Methods.- 3.2 Biochemical Investigations with Filterable Viruses.- 3.3 Are Cell Inclusions Specific to Filterable Viruses?.- 3.4 Culturing Filterable Viruses In Vivo and In Vitro.- 3.5 Filterable Viruses as Antigens.- 3.6 Filterable Viruses as Pathogens.- 3.7 Viruses are not Just Very Small Bacteria.- 4 On the Way to a Definition of the Virus.- 4.1. Viruses as Pathogens.- 4.2 A Biochemical Approach to the Virus.- 4.3 Viruses as Genetic Macromolecules.- 4.4 What Exactly is a Virus?.- 5 The Period of Biochemistry and Molecular Genetics.- 5.1 The Virion.- 5.2 The Virus Multiplication Cycle.- 5.3 Viruses as Pathogens.- 5.4 Viruses and Immunity.- 5.5 Viral Pathogenicity.- 5.6 Virus Chemotherapy.- Epilogue.- Name Index.