Biomedical Applications of Proteomics

PrefaceSECTION I: ASPECTS OF BIOMEDICAL RESEARCHProteomics in Biomedicine - A Tool, a Science or an Art?SECTION II: BLOOD VESSELSAntibody-Based Vascular Targeting: Proteomic Techniques for the Identification and Quantitation of Membrane Proteins on Endothelial CellsVasculature, Vascular Disease and AtherosclerosisDiscovery of New Diagnostic Markers of StrokeSECTION III: CANCERUnravelling Biological Pathways and the Identification of Clinical Markers and Targets in Renal CancerHSP27 in CancerProteomic Approaches for Biomarker Discovery in Colorectal CancerClinical Proteomics: Ovarian CancerProtein Expression Profiling Analysis in Hematopoietic Stem Cells: Phenotypic Characterization of Mesenchymal Stem CellsLymphoblastoid and Lymphoma CellsSECTION IV: PHARMACO-TOXICOLOGYChemoresistance in Cancer CellsDiabetes Mellitus: Complex Molecular Alterations)SECTION V: INFECTIOUS DISEASESProteome Approach to Infectious DiseasesNew Insights Into HIV Lymphocyte InfectionModifications of Host-Cell Proteomes Induced by Herpes Virus Type 1Francisella TularensisSECTION VI: CENTRAL NERVOUS SYSTEMProteomics in Clinical NeurosciencesHuman Cerebrospinal FluidProteomic Applications for Molecular Assessment of Alzheimer's DiseaseSECTION VII: MASS SPECTROMETRY AND BIOINFORMATICSMALDI MS Imaging in Biomedical ResearchProtein Variations: Resources and Tools

Jean-Charles Sanchez has been working since 1989 in the field of proteomics. He contributed in the development of two-dimensional polyacrylamide gel electrophoresis and related procedures and their application in Biomaker discovery research. He obtained his Ph.D. in Biochemistry at the Buckingham University (UK) and in 1997 a Business Administration diploma (Officer School of Lausanne). Since 1995, he has been the head of the Biomedical Proteoomics Group at the BPRG at the Geneva University Hospital. He is a founder of the Swiss Proteomics Society, Swiss-2Dservice and Phenomics Sciences Consulting. The activities in his group cover the discovery of new disease markers and drug targets in multi-factorial disorders including cancer, Alzheimer, CJD, stoke, obesity and type II diabetes.
Garary L. Corthals has been involved in proteomics for over 10 years and has focused on integrating MS technologies for protein analysis in biomedical research. His current interests include development of technologies for rapid and sensitive protein analysis to discover new diagnostic markers for disease and to elucidate cellular processes that direct physiological behaviour. Other activities include the synthesis of new chemistries for accurate quantitation or proteins and the concurrent analysis of PTMs; as well as technologies for capturing high density protein profiles. He obtained his Ph.D. in Biology at Macquarie University (Australia) in the field of proteomics. Before arriving in Geneva he worked in the Department of Molecular Biotechnology (UW, Seattle) and directed the Proteomics Facility at the Garvan Institute of Medical Research in Sydney (Australia). He currently heads the MS Group at the BPRG at Geneva University Hospital and is co-director of the Proteomics Facility of the Faculty of Medicine.

Denis F. Hochstrasser is the director of the Clinical Pathology Department and Head of the Clinical Chemistry Laboratory of the Geneva University Hospital. He obtained his M.D.

"In spite of the complexity of many diseases as well as proteomic approaches that may be applied, the style of the book is generally clear and straightforward in its presentation." - Proteomics

"This book is a good reference resource for all academic and other researchers who are interested in how proteomics is applied in biomedicine." - E-STREAMS

"... a nice overview of biomedical proteomics applications." - Clinical Chemistry

"...those new to the field can use the book to quickly catch up on applications of proteomics. ... the book [is also] a great resource for literature and techniques." - Environmental Health Perspectives

"...this book is a compendium of biomedical publications covering a wide range of state-of-the-art proteomic techniques and aimed to give a detailed view what current proteomic technologies can serve for in biomedical research. The clear style of the book and its straightforward presentations provides profound insight to scientists. Furthermore, it serves as a good resource for literature and techniques for academic and other researchers interested in the implementation of proteomics in biomedicine. (...) Overall the editors provide a comprehensive overview on biomedical proteomics applications for both, protein analysts familiar with state-of-the-art proteome technologies as well as physicians in molecular medicine." - Arneimittel-Forschung/Drug Research

"In spite of the complexity of many diseases as well as proteomic approaches that may be applied, the style of the book is generally clear and straightforward in its presentation."Proteomics"This book is a good reference resource for all academic and other researchers who are interested in how proteomics is applied in biomedicine."E-STREAMS"... a nice overview of biomedical proteomics applications."Clinical Chemistry"...those new to the field can use the book to quickly catch up on applications of proteomics. ... the book [is also] a great resource for literature and techniques."Environmental Health Perspectives"...this book is a compendium of biomedical publications covering a wide range of state-of-the-art proteomic techniques and aimed to give a detailed view what current proteomic technologies can serve for in biomedical research. The clear style of the book and its straightforward presentations provides profound insight to scientists. Furthermore, it serves as a good resource for literature and techniques for academic and other researchers interested in the implementation of proteomics in biomedicine. (...) Overall the editors provide a comprehensive overview on biomedical proteomics applications for both, protein analysts familiar with state-of-the-art proteome technologies as well as physicians in molecular medicine."Arneimittel-Forschung/Drug Research