Cell-Based Therapy for Degenerative Retinal Disease

Advantages of the Eye as a Target Organ for Cell-Based Therapy in the Central Nervous System.- Proof of Principle: Preclinical Data on Retinal Cell Transplantation.- Clinical and Pathological Features of Selected Human Retinal Degenerative Diseases.- Degenerative Retinal Diseases: Cells sources for cell-based therapy.- Manufacturing of Clinical Grade Cellular Products Under Gmp Conditions.- Regulatory Requirements for Cell-Based Therapy for Degenerative Retinal Disease.- Biomaterials and Scaffolds for Cell Replacement Therapy.- Restoration of cone photoreceptor function in retinitis pigmentosa (RP) - retinal cell-based therapy.- Cell Delivery: Surgical Approaches.- Diagnosis and Complementary Examinations.- Cell Therapy for Degenerative Retinal Disease: special focus on cell fusion-mediated regeneration.- Clinical Trials of Retinal Cell Therapy.- Future Directions.- Index.

Dr. Zarbin graduated from the Johns Hopkins University School of Medicine (Medical Scientist Training Program, th ) and completed resident and fellowship training (vitreoretinal surgery and medical retina) at the Wilmer Ophthalmological Institute. Dr. Zarbin is Chair of the Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School and Chief of Ophthalmology at University Hospital in Newark, N.J. He is a Professor of Ophthalmology and Neuroscience and is the Alfonse A. Cinotti, MD/Lions Eye Research Chair. Dr. Zarbin is co-Director of the Ocular Cell Transplantation Laboratory. Dr. Zarbin has published 221 peer-reviewed papers and editorials, 100 book chapters, one book on age-related macular degeneration, one book on stem cell therapy for degenerative retinal disease, and two books on the management of diabetic retinopathy.

Dr. Zarbin is a Vice Chair of the Scientific Advisory Board of the Foundation Fighting Blindness, Editor-in-Chief ofTranslational Vision Science and Technology, is a member of the editorial board of Ophthalmology, Ophthalmology Retina, and the Journal of Vitreoretinal Diseases, and is an ex officio member of the National Advisory Eye Council. He is also a member of the American Ophthalmological Society, Academia Ophthalmologica Internationalis, the Retina Society, the Macula Society, the Gonin Society, and the ASRS. Dr. Zarbin is an ARVO Fellow, Gold Level.

Dr. Mandeep S. Singh, M.D., Ph.D., graduated from the School of Medicine, National University of Singapore in 2001 and completed his residency in ophthalmology at the National University Hospital of Singapore. He obtained a Ph.D. in ophthalmology at the University of Oxford, United Kingdom in 2013. He completed his fellowship training in medical and surgical retina at the Oxford Eye Hospital and Moorfields Eye Hospital, United Kingdom.He is Assistant Professor of Ophthalmology in the Retina Division of the Wilmer Eye Institute,