Cell Biology of Extracellular Matrix
(Sprache: Englisch)
At a recent meeting to discuss the domains of cell biology, I put forth a case for the extracellular matrix, even though my argument ran the risk of falling on deaf ears. After all, the matrix is EXTRAcellular, outside the cells. In this book, however, the...
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Klappentext zu „Cell Biology of Extracellular Matrix “
At a recent meeting to discuss the domains of cell biology, I put forth a case for the extracellular matrix, even though my argument ran the risk of falling on deaf ears. After all, the matrix is EXTRAcellular, outside the cells. In this book, however, the authors make a compelling case for the relevance of the matrix to cellular concerns. Not only are numerous cell types, including many epithelia, quite caught up in the business of manufacturing matrix components, but also most of them contain matrix molecules in exoskeletons that are attached to the plasmalemma and that organize or otherwise influence the affairs of the cyto plasm. The idea of this book is to present the extracellular matrix to cell biolo gists of all levels. The authors are active and busy investigators, recognized experts in their fields, but all were enthusiastic about the prospect of writing for this audience. The chapters are not "review" articles in the usual sense, nor are they rehashes of symposium talks; they were written specifically for this book and they present the "state of the art" in engaging style, with ample references to more technical or historical reviews. The book is rich in electron micro graphs and diagrams and for many of the latter, as well as for the design of the cover, we are indebted to Sylvia J. Keene, medical illustrator for the Department of Anatomy at Harvard Medical Scrool. We also owe special thanks to Susan G.
Inhaltsverzeichnis zu „Cell Biology of Extracellular Matrix “
'Introductory Remarks.- I. What is Extracellular Matrix?.- 1 Collagen.- 1. Introduction.- 2. The Collagen Molecule.- 2.1. Triple-Helical Region.- 2.2. Non-Triple-Helical Region.- 3. Posttranslational Modifications.- 3.1. Proline.- 3.2. Lysine.- 4. Molecular Arrangement in Native Fibrils.- 5. Procollagen.- 6. Genetic Types of Collagen.- 6.1. The Interstitial Collagens: Types I, II, and III.- 6.2. Collagen Types IV and V.- 7. Immunology of Collagen.- 7.1. Conventional Antibodies.- 7.2. Monoclonal Antibodies.- 8. Concluding Remarks.- References.- 2 Proteoglycans.- 1. Introduction.- 2. Cartilage Proteoglycans.- 2.1. Structure.- 2.2. Assembly, Secretion, and Aggregation.- 2.3. Functional Aspects.- 3. Proteoglycans in Other Tissues.- 3.1. Aorta.- 3.2. Corneal Stroma.- 3.3. Ovarian Follicular Fluid.- 3.4. Basal Lamina.- 3.5. Plasma Membranes.- 4. Concluding Remarks.- References.- 3 Elastin.- 1. Introduction.- 2. Isolation of Elastin.- 3. Solubilization of Elastin.- 3.1. Chemical.- 3.2. Enzymatic.- 4. Mechanical Properties.- 5. Morphology and Distribution.- 6. Amino Acid Composition.- 7. Cross-Linking.- 8. Soluble Elastins.- 8.1. Tropoelastin.- 8.2. Relationship of Tropoelastin to Insoluble Elastin.- 8.3. Peptide Models of Tropoelastin.- 8.4. Other Soluble Elastins.- 8.5. Sequencing of Tropoelastin.- 8.6. Antigenicity of Elastin and Its Derivatives.- 8.7. Cell-Free Translations.- 9. Microfibrils.- 10. Formation of Elastin in Cell and Organ Cultures.- 11. Concluding Remarks.- References.- 4 Fibronectin and Other Structural Proteins.- 1. Introduction.- 2. Fibronectin.- 2.1. Types of Fibronectin.- 2.2. Location of Fibronectin.- 2.3. Molecular Properties of Fibronectin.- 2.4. Specific Structural and Functional Domains.- 2.5. Cell Receptor for Fibronectin.- 2.6. Biosynthesis of Fibronectin.- 3. Laminin.- 4. Chondronectin.- 5. Concluding Remarks.- References.- II. How Do Cells Produce the Matrix?.- 5 Proteoglycan Biosynthesis.- 1. Introduction.- 2. Synthesis of Core Protein.-
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2.1. Variation in Structure of Core Protein.- 2.2. Cell-Free Synthesis of Core Protein.- 3. Synthesis of Chondroitin Sulfate.- 3.1. Chain Initiation.- 3.2. Synthesis of Galactosyl-Xylosyl Protein Linkage.- 3.3. Completion of Linkage Region.- 3.4. Chain Elongation.- 3.5. Sulfation.- 3.6. Chain Termination.- 4. Keratan Sulfate Synthesis.- 5. Hyaluronic Acid Synthesis.- 6. Study of Proteoglycan Synthesis in Vivo.- 6.1. Sulfate Incorporation.- 6.2. Measurement of Core Protein.- 6.3. Measurement of Xylosyltransferase.- 6.4. Use of Xylosides.- 7. Control and Localization of Synthesis of Matrix Components.- 7.1. Control of Synthesis of Matrix Components.- 7.2. Localization of Proteoglycan Synthesis, Secretion, and Aggregation.- 8. Concluding Remarks.- References.- 6 Collagen Biosynthesis.- 1. Introduction.- 2. Structure of Procollagens.- 3. Collagen Gene Structure and Regulation of mRNA Levels.- 3.1. Synthesis and Cloning of Collagen cDNA Probes.- 3.2. Isolation of Collagen Gene Fragments from Genomic Libraries.- 3.3. Structure of a Collagen Gene.- 3.4. Regulation of Collagen mRNA Levels.- 4. Cotranslational and Posttranslational Modifications of Intracellular Procollagen.- 4.1. Cell-Free Translation of Collagen mRNA.- 4.2. Intracellular Location of Posttranslational Modifications.- 4.3. Hydroxylation of Prolyl and Lysyl Residues.- 4.4. Disulfide-Bond Formation and Triple-Helix Formation.- 4.5. Glycosylation of Hydroxylysyl Residues.- 4.6. Glycosylation of Asparagine Residues in Propeptides.- 5. Intracellular Transport of Procollagen.- 5.1. The Role of the Golgi Complex in Procollagen Processing and Packaging.- 5.2. The Packaging of Procollagen Aggregates in Secretory Granules.- 6. Extracellular Processing of Procollagen.- 6.1. Procollagen Proteases.- 6.2. Dermatosparaxis-A Procollagen Processing Defect.- 7. Regulation of Collagen Synthesis.- 8. Concluding Remarks.- References.-
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Bibliographische Angaben
- Autor: Elizabeth D. Hay
- 2011, 1981, 417 Seiten, 1 farbige Abbildungen, Maße: 17 x 24,4 cm, Kartoniert (TB), Englisch
- Verlag: Springer, Berlin
- ISBN-10: 1461282268
- ISBN-13: 9781461282266
Sprache:
Englisch
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